2015, Number 1
<< Back Next >>
Rev Cubana Farm 2015; 49 (1)
Spray drying of calcium and magnesium citrate from dolomite
Rodríguez CJE, López HOD, Blanco CO, Nogueira MA, López AM
Language: English
References: 19
Page: 29-37
PDF size: 90.26 Kb.
ABSTRACT
Introduction: calcium is an essential nutrient required in substantial amounts, but
many diets are deficient in calcium making supplementation necessary or desirable.
On the other hand, spray drying is an important technology used in the
pharmaceutical industry. In this process the end-product must comply with precise
quality standards.
Objective: To evaluate the spray drying of calcium and magnesium citrate and to
make comparison with the traditional method of drying.
Methods: calcium and magnesium citrate salt was obtained at bench scale from
dolomite and suspended in water in a proportion 1:10 (w/v) and spray-dried. The
final batches were evaluated by chemical and technological analysis methods.
Results: the results showed that calcium, magnesium, citric acid and total ash
content have similar concentrations regardless of the used drying method. Residual
moisture content of the dried product by spray drying method was higher than that
of the dried sample by traditional method. Nevertheless, all the results were below
the maximum allowable limit. The physical properties of the samples for each
drying method were similar except for density because the spray-dried samples
showed values lower than those of traditionally dried samples.
Conclusions: the results indicate that the tested spray drying conditions are suitable for drying of calcium and magnesium citrate from dolomite.
REFERENCES
Hickey A, Ganderton D. Drying. In: Pharmaceutical Process Engineering. Drugs and the Pharmaceutical Science. Vol 112. Cap 6. New York, USA:Marcell Dekker Inc; 2001. p.86-109.
Gil M, Vicente J, Gaspar F. Scale-up methodology for pharmaceutical spray drying. Chemistry Today. 2010; 28(4):18-22.
Patel R, Patel M, Suthar A. Spray drying technology: an overview. Indian Journal of Science and Technology. 2009; 2(10):44-47.
Hanzlik R, Fowler S, Fisher D. Relative Bioavailability of Calcium from Calcium Formate, Calcium Citrate, and Calcium Carbonate. JPET. 2005;313(3):1217–1222.
Heaney R P. Factors influencing the measurement of bioavailability, taking calcium as a model. J Nutr 2001; 131: S1334–S1348.
Sakhaee K, Bhuket T, Adams-Huet B, Sudhaker Rao D. Meta-analysis of calcium bioavailability: a comparison of calcium citrate with calcium carbonate. Am J Ther. 1999;6:313–321.
Rodríguez Chanfrau JE, Graveran T, Rodríguez I, Díaz I, Roberto Y, Mateus L, et al. Proceso de obtención de citrato de calcio y magnesio a partir de dolomíta. Patente CO1F 1/00; A61K 33/06, A61K 9/00, C07C 51/41. Certificado 22794. 2002.
Rodríguez Chanfrau J E, López Hernández OD, Nogueira Mendoza A. Calcium magnesium citrate drying at bench scale. Rev Cubana Farm. 2009;43(1). [cited 2014 feb 08]; Available from: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034- 75152009000100004&lng=es&nrm=iso .
Vidal S, Saleeb Fouad Z. Calcium Citrate anticaking agent. United States patent US 5208372;1993.
Rodríguez Chanfrau JE, Lagarto Parra A, Bueno Pavón V, Guerra Sardiña I, Vega Hurtado Y. Effectiveness of washout process to obtain calcium and magnesium citrate at bench scale. Rev Cubana de Farm. 2010;45(1):5-12.
USP. United States Pharmacopoeia 31. US Pharmacopoeia Convention, Inc. Washington DC. 2008; p. 149, 753 – 757, 1914 – 1917, 2834 – 2838.
Iraizoz A, Bilbao O, Barrios MA. Conferencias de Tecnología Farmacéutica. Ed. ENPES. La Habana; Cuba: 1990.
Rodríguez Chanfrau JE, Martinez Alvarez L, Bermello Crespo A. Evaluation of calcium and magnesium citrate obtained from Cuban dolomite. Rev Cubana de Farm. 2014;48(4).
Ré MI. Microencapsulation by spray drying. Drying Technology. 1998;16(6):1195-1136.
Nath S, Sapathy GR. A systematic approach for investigation of spray drying process. Drying Technology. 1998;16(6):1173-1193.
Santos Souza A, Vilela Borgues S, Ferreira Magalhaes N, Vaz Ricardo H, Pascoli Cereda M, Regina Daiutos E. Influence of spray drying conditions on the physical properties of dried pulp tomato. Ciênc. Tecnol. Aliment. 2009;29(2):291-294.
Rodríguez Chanfrau JE, Fuste Moreno V.Citrato de calcio. Ficha técnica de control de la calidad. Centro de Investigación y Desarrollo de Medicamentos. La Habana, Cuba: BioCubaFarm;2002.
Walton D. E. The morphology of spray dried particles: a qualitative view. Drying Technology. 2000;18(9):1943-86.
Chegini G. R, Ghobadian B. Effect of spray drying conditions on physical properties of orange juice powder. Drying Technology, 2005;23(3):657-668.