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ISSN 1561-3011 (Electronic)

2015, Number 3

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Rev Cubana Invest Bioméd 2015; 34 (3)

Transient receptor potential ion channels and their leading role in analgesic therapy

Galán ML, Souto CRD, Valdés GS, Minaberriet CE

Language: Spanish
References: 38
Page: 278-288
PDF size: 143.25 Kb.


ABSTRACT

In the search for new therapeutic options for pain treatment, new ion channels have been discovered, which act as receptors and are present in primary afferent nociceptor neurons. Some of them are the transient receptor potential ion channels that regulate the pathways involved in pain and nociception. An updated review of the main transient potential receptors ion channels involved in pain physiopathology and a historical review of the discovery of these molecules and advanced studies on them were also made. Then the different families of these channels with their classification, nomenclature, structure and cell functions were also examined. An account of the relationships of these channels with analgesia as well as the mechanism of action of some analgesics acting upon them was also presented. Finally, important considerations were given, which should be taken into account since they might influence on the clinical use of these drugs. For these reasons, the paper intends to be a review covering the role of the transient receptor potential channels as new pharmacological targets in the pain treatment.


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