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2015, Number 4

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Evid Med Invest Salud 2015; 8 (4)

MicroRNAs: new actors in obesity

Heredia-Melo L, Castańón-Sánchez CA, Marchat LA

Language: Spanish
References: 38
Page: 172-179
PDF size: 349.84 Kb.


ABSTRACT

Obesity and associated diseases represent a major public health problem worldwide. In addition to restricted diets, lifestyle changes and medical therapies, bariatric surgery is the recommended treatment for people with morbid obesity. The identification of the molecular mechanisms underlying this metabolic disorder showed the relevance of epigenetic regulation. Notably, microRNAs are small non-coding RNA molecules that regulate gene expression by targeting messenger RNA for degradation or translational repression. They have been shown to play important regulatory roles in a variety of biological processes related to obesity, including adipocyte differentiation, metabolic integration, and insulin resistance, among others. In this review, we describe the identification and role of selected microRNAs in obesity and related metabolic diseases. We also present some data about the regulatory effect of bariatric surgery on these molecules, which can support the physical and biochemical changes observed in the patient. This knowledge highlights the potential of microRNAs as biomarkers for obesity.


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