medigraphic.com
ISSN 1561-2929 (Print)

2015, Number 2

<< Back Next >>

RCAN 2015; 25 (2)

Oxidative stress and nutritional status of the elderlies living in an urban community of the county of Playa, Havana City

Cabrera GJ, Barrios VO, Díaz-Canell FAM, Basanta FD

Language: Spanish
References: 77
Page: 327-340
PDF size: 378.75 Kb.


ABSTRACT

Rationale: Oxidative stress might be aggravated with age, and influence the course of aging. Objective: To assess the redox status redox of elderlies living without restrictions in the community. Study design: Observational, analytical. Material and method: The presence of products derived from oxidation of lipids and proteins, and the activity of superoxidedismutase and catalase enzymes were assayed in 97 elderlies with ages between 70 and 99 years, living in the county of Playa (Havana City, Cuba). Redox variables were distributed according with anthropometric and biochemical indicators of the elderly´s nutritional status. Results: The elderly´s redox status was independent from the nutritional status (indistinctly determined by means of the Body Mass Index or the Mini Nutritional Assessment score). Negative associations (albeit modest) were observed between products of oxidation of proteins and serum albumin, on one hand; and between super-oxide dismutase activity and lymphocyte count, on the other. Conclusions: Elderly´s redox status might reflect|compound the influence of the occurrence of noncommunicable chronic diseases that might result in inflammation, sarcopenia, and hypoalbuminemia. Senescence of the immune system, and pro-oxidative damage, might also contribute to diminished activity of the systems scavenging for oxygen reactive species.


REFERENCES

  1. Kirkwood TB, Kirkwood TBL. Time of our lives: The science of human aging. Oxford University Press. New York: 1999.

  2. Restrepo HE, Rozental M. The social impact of aging populations: Some major issues. Social Science Medicine 1994; 39:1323-38.

  3. Dobriansky PJ, Suzman RM, Hodes RJ. Why population aging matters: A global perspective. Department of State. Department of Health and Human Services. National Institute on Aging from the National Institutes of Health. Washington DC: 2007. Disponible en: http://www.state.gov/g/oes/rls/or/81537. htm/. Fecha de última visita: 3 de Febrero del 2015.

  4. Beard J, Officer A, Cassels A. Informe mundial sobre el envejecimiento y la salud. OMS Organización Mundial de la Salud. Ginebra: 2015. ISBN: 978-92-4- 356504-0.

  5. Palloni A, Pinto-Aguirre G, Pelaez M. Demographic and health conditions of ageing in Latin America and the Caribbean. Int J Epidemiol 2002;31: 762-71.

  6. Wong R, Peláez M, Palloni A, Markides K. Survey data for the study of aging in Latin America and the Caribbean. Selected studies. J Aging Health 2006; 18:157-79.

  7. Hernández Castellón R. El envejecimiento de la población en Cuba. Estudios Demográficos Urbanos 1992; 7(2/3):603-17.

  8. ONE Oficina Nacional de Estadísticas. Anuario Estadístico. MINSAP Ministerio de Salud Pública. La Habana: 2011.

  9. MINSAP Ministerio de Salud Pública. Geriatría y Gerontología. Programa de desarrollo de la especialidad. Editorial Ciencias Médicas. La Habana: 2002.

  10. Partridge L, Gems D. The evolution of longevity. Current Biology 2002; 12:R544-R546.

  11. Rowe JW, Kahn RL. Human aging: Usual and successful. Science 1987; 237:143-9.

  12. Getzen TE. Population aging and the growth of health expenditures. J Gerontology 1992;47:S98-S104.

  13. Lima Costa MF, Veras R. Saúde pública e envelhecimento. Cadernos de Saúde Pública 2003;19(3):700-1.

  14. Lubitz J, Cai L, Kramarow E, Lentzner H. Health, life expectancy, and health care spending among the elderly. New Engl J Med 2003;349:1048-55.

  15. Santrock JW. Life-span development. McGraw-Hill. Boston, MA: 2009.

  16. Blagosklonny MV. Why human lifespan is rapidly increasing: Solving "longevity riddle" with "revealed-slow-aging" hypothesis. Aging [Albany] 2010;2:177-82.

  17. Christensen K, Johnson TE, Vaupel JW. The quest for genetic determinants of human longevity: Challenges and insights. Nature Reviews Genetics 2006; 7:436-48.

  18. Herskind AM, McGue M, Holm NV, Sörensen TI, Harvald B, Vaupel JW. The heritability of human longevity: A population-based study of 2,872 Danish twin pairs born 1870-1900. Human Genetics 1996;97:319-23.

  19. Franceschi C, Bonafe M. Centenarians as a model for healthy aging. Biochem Soc Trans 2003;31:457-61.

  20. Perls T, Terry D. Understanding the determinants of exceptional longevity. Annals Intern Med 2003;139(5 Part 2):445-9.

  21. De Groot L, Verheijden MW, De Henauw S, Schroll M, Van Staveren WA. Lifestyle, nutritional status, health and mortality in elderly people across Europe: A review of longitudinal results of the SENECA study. J Gerontol A Bio Sci Med Sci 2004;59A(12):1277-84.

  22. Le Bourg, É. (2001). A mini-review of the evolutionary theories of aging. Is it the time to accept them. Demographic Research 2001;4:1-28.

  23. Weinert BT, Timiras PS. Physiology of aging: Invited review. Theories of aging. J Appl Physiol 2003;95:1706-16.

  24. Gall JS, Suabo PA. Core concepts: Psychosocial aspects of aging. Clin Geriatr 2002;10:48-52.

  25. Gilberto PA. Consideraciones generales sobre algunas de las teorías del envejecimiento. Rev Cubana Invest Biomed 2003;22:53-62.

  26. Zorrilla AE. El envejecimiento y el estrés oxidativo. Rev Cubana Invest Biomed 2002;21:178-85.

  27. Gutteridge J. Ageing and free radicals. Med Lab Sci 1992;49:313-8.

  28. Rodríguez Pascual Y, Vázquez Fernández R, Infantes Hernández Z, Lavernia Pineda L, Robles Ochoa Y. Envejecimiento y estrés oxidativo. Correo Científico Médico 2009;13(2):0- 0. Disponible en: http://www.cocmed.sld.cu/no132/no132r ev3.htm. Fecha de última visita: 23 de Agosto del 2015.

  29. Sohal RS, Mockett RJ, Orr WC. Mechanisms of aging: An appraisal of the oxidative stress hypothesis. Free Radical Biology Medicine 2002;33: 575-86.

  30. Apel K, Hirt H. Reactive oxygen species: Metabolism, oxidative stress, and signal transduction. Annu Rev Plant Biol 2004; 55:373-99.

  31. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000;408(6809):239-47.

  32. Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J. Aging and genome maintenance: Lessons from the mouse. Science 2003;299:1355-9.

  33. Inoue M, Sato EF, Nishikawa M, Park A. M, Kira Y, Imada I, Utsumi K. Mitochondrial generation of reactive oxygen species and its role in aerobic life. Current Medicinal Chemistry 2003; 10:2495-2505.

  34. Yu BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994;74:139-62.

  35. Kohen R, Vellaichamy E, Hrbac J, Gati I, Tirosh O. Quantification of the overall reactive oxygen species scavenging capacity of biological fluids and tissues. Free Radical Biology Medicine 2000;28:87179.

  36. Mates JM. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 2000;153:83-104.

  37. Kayanoki Y, Fujii J, Islam KN, Suzuki K, Kawata S, Matsuzawa Y; et al. The protective role of glutathione peroxidase in apoptosis induced by reactive oxygen species. J Biochem 1996;119:817-22.

  38. Battin EE, Brumaghim JL. Antioxidant activity of sulfur and selenium: A review of reactive oxygen species scavenging, glutathione peroxidase, and metalbinding antioxidant mechanisms. Cell Biochem Biophys 2009;55:1-23.

  39. García Rodríguez I, Camps Calzadilla E, Gámez Fonseca M, Santana Porbén S; para el Grupo Cubano de Estudio de los Centenarios. Estado nutricional y desempeño físico de centenarios radicados en las provincias habaneras. RCAN Rev Cubana Aliment Nutr 2010; 20:287-303.

  40. Camps Calzadilla E. Características antropométricas, funcionales y nutricionales de los centenarios cubanos. Tesis presentada en opción al grado científico de Doctor en Ciencias Médicas. MINSAP Ministerio de Salud Pública. La Habana: 2012.

  41. García Rodríguez I, Rodríguez Izquierdo E, Camps Calzadilla E, Gámez Fonseca M. Cambios corporales asociados al envejecimiento en ratas Sprague- Dawley. RCAN Rev Cubana Aliment Nutr 2011;21:4-13.

  42. Cabrera González J, Barrios Viera O, Díaz-Canell AM, Basanta Fortes D. Estado nutricional de los ancianos domiciliados en una comunidad urbana del municipio habanero de Playa. RCAN Rev Cubana Aliment Nutr 2015;25: 92-105.

  43. Guigoz Y, Vellas B. The MiniNutritional Assessment (MNA) for grading the nutritional state of elderly patients: Presentation of the MNA, history and validation. En: MiniNutritional Assessment (MNA): Research and practice in the elderly [Editores: Vellas B, Garry PJ, Guigoz Y]. Nestlé Nutrition Workshop Series Clinical & Performance Programme. Vol. 1. Karger AG. Basilea: 1999. pp 3.

  44. Cuyac Lantigua M, Santana Porbén S. La Mini Encuesta Nutricional del Anciano en la práctica de un Servicio hospitalario de Geriatría: Introducción, validación y características operacionales. ALAN Arch Latinoam Nutr 2007;57:255-65.

  45. Weiner JA, Lourie JA. Practical Human Biology. Academic Press. London: 1981.

  46. Lohman TG, Roche A, Martorell R. Anthropometric standardization reference manual. Human Kinetics Books. Primera Edición. Champaign, Illinois: 1988.

  47. Díaz Sánchez ME. Manual de antropometría para el trabajo de nutrición. INHA Instituto de Nutrición e Higiene de los Alimentos. La Habana: 2003.

  48. Roubenoff R, Wilson PW. Advantage of knee height over height as an index of stature in expression of body composition in adults. Am J Clin Nutr 1993;57:609-13.

  49. Waterlow JC. Classification and definition of protein-calorie malnutrition. Br Med J 1972; 3(5826):566-9.

  50. WHO Working Group. Use and interpretation of anthropometric indicators of nutritional status. Bulletin of the World Health Organization 1986;64:929-41.

  51. Santana Porbén S. Evaluación bioquímica del estado nutricional del paciente hospitalizado. Nutrición Clínica [México] 2003;6:293-311.

  52. Esterbauer H, Cheeseman K.H. Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal. Meth Enzymol 1990;186:407-21.

  53. Witko-Sarsat V, Friedlander M. Advanced oxidation protein products as novel mediators of inflammation and monocytes activation in chronic renal failure. J Immunol 1998;161:2524-32.

  54. Marklund SL, Holme E, Hellner L. Superoxide dismutase in extracellular fluids. Clinica Chimica Acta 1982; 126:41-51.

  55. Benzie Iris F, Strain JJ. The Ferric Reducing Abillity of Plasma (FRAP) as a Measure of “Antioxidant power”: The FRAP Assay. Anal Biochem 1996; 239:70-6.

  56. Beers RF, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 1952;195:133-40.

  57. Santana Porbén S, Martínez Canalejo H. Manual de Procedimientos Bioestadísticos. Segunda Edición. EAE Editorial Académica Española. ISBN-13: 9783659059629. ISBN-10: 3659059625. Madrid: 2012.

  58. Santana Porbén S, Martínez Canalejo H. Manual de Estadísticas no Paramétricas. Editorial Publicia. Saarbrücken: 2013. ISBN: 978-3-639-55468-7.

  59. Dalle-Done I, Giustarini D, Colombo R, Rossi R, Milzani, A. Protein carbonylation in human diseases. Genes Mol Med 2003;9:169-76.

  60. Ramírez DR, Pérez JRV, Barceló MDLCG, Castro ZB, Ramírez JAE. Estrés oxidativo en ratas envejecidas. Revista Finlay Enfermedades Transmisibles 2013;3:235-40.

  61. Marin Corral J, Fontes CC, Pascual Guardia S, Sanchez F, Olivan M, Argilés JM; et al. Redox balance and carbonylated proteins in limb and heart muscles of cachectic rats. Antioxidants Redox Signaling 2010;12:365-80.

  62. Uribarri J, Cai W, Peppa M, Goodman S, Ferrucci L, Striker G, Vlassara H. Circulating glycotoxins and dietary advanced glycation endproducts: Two links to inflammatory response, oxidative stress, and aging. J Gerontol A Biol Sci Med Sci 2007;62:427-33.

  63. Peppa M, Uribarri J, Vlassara H. Aging and glycoxidant stress. Hormones [Athens] 2008;7:123-32.

  64. Gruver AL, Hudson LL, Sempowski GD. Immunosenescence of ageing. J Pathol 2007;211:144-56.

  65. Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology 2007;120:435-46.

  66. Panda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR; et al. Human innate immunosenescence: Causes and consequences for immunity in old age. Trends Immunol 2009;30:325-33.

  67. Niwa Y, Iizawa O, Ishimoto K, Akamatsu H, Kanoh T. Age-dependent basal level and induction capacity of copper-zinc and manganese superoxide dismutase and other scavenging enzyme activities in leukocytes from young and elderly adults. Am J Pathol 1993;143: 312-21.

  68. Sandhu SK, Kaur G. Alterations in oxidative stress scavenger system in aging rat brain and lymphocytes. Biogerontology 2002;3:161-73.

  69. Gautam N, Das S, Mahapatra SK, Chakraborty SP, Kundu PK, Roy S. Age associated oxidative damage in lymphocytes. Oxidative Medicine Cell Longevity 2010;3:275-82.

  70. Garcia Arumi E, Andreu AL, Lopez Hellin J, Schwartz S. Effect of oxidative stress on lymphocytes from elderly subjects. Clin Sci 1998;94(Pt 4):447-52.

  71. Halliwell B. Antioxidants in human health and disease. Ann Rev Nutr 1996; 16:33-50.

  72. Seifried HE, Anderson DE, Fisher EI, Milner JA. A review of the interaction among dietary antioxidants and reactive oxygen species. J Nutr Biochem 2007; 18:567-79.

  73. Bunker V. Free radicals, antioxidants and ageing. Med Lab Sci 1992;49: 299- 312.

  74. Lee J, Koo N, Min DB. Reactive oxygen species, aging, and antioxidative nutraceuticals. Comprehensive Rev Food Sci Food Safety 2004;3:21-33.

  75. Girodon F, Blache D, Monget AL, Lombart M, Brunet-Lecompte P, Arnaud J; et al. Effect of a two-year supplementation with low doses of antioxidant vitamins and/or minerals in elderly subjects on levels of nutrients and antioxidant defense parameters. J Am Coll Nutr 1997;16:357-65.

  76. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann Internal Med 2005; 142:37-46.

  77. Temple NJ. Antioxidants and disease: More questions than answers. Nutrition Research 2000;20:449-59.




2020     |     www.medigraphic.com