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2015, Number 2

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RCAN 2015; 25 (2)

Urine urea nitrogen estimated from the ureacreatinine index constructed for a single urine sample

García AL, Santana PS

Language: Spanish
References: 35
Page: 314-326
PDF size: 475.17 Kb.


ABSTRACT

Rationale: Metabolism is the process by which nutrients contained within food are put into motion, thanks to the activity of cells and tissues, and cell structures are renewed continuosly. Nitrogen administered appearing as urea in urine might be an indicator of the subject´s metabolic activity. Objective: To assess the effectiveness of the Urea-Creatinine index (IUrCr) constructed for a single urine simple as estimator of the excretion of urine urea nitrogen (UUN). Study design: Analytical, prospective, observational. Study serie: UrCr (mg/g) index was constructed with single urine samples recovered from 154 subjects (Males: 37.7%; Ages ≥ 60 years: 31.1%) transiting through different stages of the diagnostic process at the “Hermanos Ameijeiras” Clinical Surgical Hospital (Havana City, Cuba), between October 2013 and October 2014 (both months included). NUU expected for a 24 hours urine collection was predicted from the UrOCre index expressed as a fraction of the expected creatinine excretion, after adjusting for the subbject´s height. Accuracy of predicted UNN was compared with that obtained from 24 hours collections. Results: UUN predicted from the UrOCre index was comparable with the one observed with 24 hours collections: Predicted: 8.5 ± 4.7 g.24 hours-1 vs. Observed: 8.5 ± 4.7 g.24 hours-1 (t = -0.022; p › 0.05; test for paired means). Frequency of UNN values › 5 g.24 hours-1 was independent from the method used in the measurement of UUN: Predicted: 78.6% vs. Observed: 76.6% (p › 0.05; McNemar´s test for paired observations). Conclusions: Prediction of UUN from UrOCre index as constructed for single urine samples is a valid option for assessing nitrogen metabolism in hospitalized subjects.


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