Hernández VM, Zárate A

Language: Spanish
References: 36
Page: 371-377
PDF size: 63.18 Kb.

ABSTRACT

Changes in insulin action cause maternal adaptation to fetal nutrient demand. Insulin resistance generates a greater production of insulin to compensate this resistance; however, there could be failure of pancreatic b-cells to compensate by adequate insulin secretion. Factors linked to the development of gestational diabetes are: increased concentrations of placental growth hormone; peptides produced by adipose tissue, which show predictive value for the development of insulin resistance; adverse effects of intrauterine food restriction; autoimmunity induced by the consumption of some nutrients in early neonatal life; viral infections in children, which could damage pancreatic islets and become incapable of responding to metabolic overload such as pregnancy.

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