2016, Number 1
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Rev Med Inst Mex Seguro Soc 2016; 54 (1)
Scientific contributions of Jules Hirsch regarding the physiopatogenesis of obesity
Zárate A, Manuel L
Language: Spanish
References: 15
Page: 92-95
PDF size: 291.75 Kb.
ABSTRACT
Jules Hirsch was born in New York City and died at age 88 after a long
illness. He was considered notorious leader in the study of human
metabolism mainly in the area of lipids and obesity. His research at
The Rockefeller University helps establish the mechanism of obesity
and lipids metabolism. Hirsch joined Rockefeller´s faculty in 1954 and
remained there for the rest of his career. Hirsch´s research helped to
support the idea of dynamic interactions among diet, physical activity,
general metabolism and obesity. At that time most scientific considered
adipose tissue to be biologically inert such as a passive insulator in
which the body reserved energy in the form of triglycerides. Hirsch had
a natural characteristic of showing a nice smile and greeting for everyone
he worked with at the university. Another important contribution was
there relationship between diet and cardiovascular ailments as well as
metabolism disturbance.
REFERENCES
Snyder A. Jules Hirsch. Lancet. 2015;386:950.
Bardossi F, Schwartz JN. The Fat’s In the fire: [Dr. Jules Hirsch] (1985). Rockefeller University Research Profiles. Book 23
Hirsch J, Gallian E. Methods for the determination of adipose cell size in man and animals. J Lipid Res. 1968;9(1):110-9.
Faust IM, Johnson PR, Hirsch J. Noncompensation of adipose mass in partially lipectomized mice and rats. Am J Physiol. 1976;231(2):539-44.
Hirsch J, Farquhar JW, Ahrens E, Peterson M, Stoffel W. Studies of adipose tissue in man. Am J Clin Nutr. 1960;8:499-511.
Lelliot C, Vidal-Puig AJ. Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. Int J Obes. 2004;28:S22-8.
Faust IM, Johnson P, Hirsch J. Role of Adipocyte Geometry in Eating Behavior. Science. 30 June 1978:1505.
Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med. 1995,332:621-8.
Hirsch J. Obesity: Matter over mind? Cerebrum. 2003;5:7-18.
Hirsch J. One thing leads to another. J Clin Invest. 2004;114:1040-3.
Havel PJ. Update on adipocyte hormones. Regulation of energy balance and carbohydrate/lipid metabolism. Diabetes. 2004;53 (Suppl 1):S143-51.
Manuel L, Rocha L, Damasio L, Tesoro E, Zárate A. Role of prenatal undernutrition in expression serotonin, dopamine and leptin receptors in adult mice: implications of food intake. Molecular Medicine Reports. 2014;9:407-12.
Manuel L, Zárate A, Hernández M. La leptina, hormona del adipocito, regula el apetito y el consumo de la energía. Papel en la obesidad y dismetabolismo. Acta Med. 2012;10:154-7.
Zárate A, Saucedo R, Basurto L, Hernández M. El tratamiento del colesterol alterado en una encrucijada terapéutica. Rev Med Inst Mex Seguro Soc. 2012;50:1-4.
Zárate A, Manuel L, Basurto L, de la Chesnaye E, Saldívar I. Colesterol y aterosclerosis. Consideraciones históricas y tratamiento. Archivos de Cardiología de México. 2015. En Prensa.