Nava-González EJ, Cerda-Flores RM, García-Hernández PA, Jasso-de la Peña GA, Bastarrachea RA, Gallegos-Cabriales EC

Language: Spanish
References: 38
Page: 731-740
PDF size: 109.19 Kb.

ABSTRACT

Introduction: There are few studies integrating the common causes of osteoporosis and obesity (disorders of body composition). A first step is to investigate correlations between their biological phenotypes to determine their common integrative physiology. Objective: To correlate the variation of bone mineral density with phenotypes of body composition and biomarkers of bone physiology, insulin-glucose axis, and adipose tissue. Methods: Cross-sectional study of 75 women (aged 18-45 years). Measurements: Body mass index, waist, fat mass, lean mass (dual-energy X-ray absorptiometry), glucose, insulin, osteocalcin, leptin, tumor necrosis factor alpha. Statistical analysis: multivariate general linear model, SPSS v.22, p ‹ 0.05.Results: Age: 32.08 ± 7.33. Bone mineral content multivariate general linear model 1 with two phenotypes excluded (glucose, insulin): osteocalcin (β = –0.228, p = 0.011), lean mass (β = 0.606, p = 0.001) and fat mass (β = 1.237, p = 0.001) in 62.0%. The bone mineral density multivariate general linear model 2 with three phenotypes excluded (body mass index, glucose, tumor necrosis factor alpha): insulin (β = 0.250, p = 0.024), osteocalcin (β = –0.362, p = 0.001), lean mass (β = 0.512, p = 0.001) and fat mass (β = 0.701, p = 0.001) in 46.3%. Conclusions: Results show that body composition with an increased lean mass is beneficial to bone. This study reaffirms the importance of performing regular exercise to prevent muscle loss.

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