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2015, Number 2

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Rev Cubana Invest Bioméd 2015; 34 (2)

Hepatic, pancreatic and alveolar repercussions of altered zinc and vitamin homeostasis in smoking and alcoholism

Ramírez EOE, Cáceres DA, Benítez AG, Núñez BAI, Reyes MR, Morales LCE

Language: Spanish
References: 78
Page: 187-203
PDF size: 173.95 Kb.


ABSTRACT

The purpose of the study was to explain the association between altered homeostasis of zinc and some vitamins and its hepatic, pancreatic and alveolar repercussions in smokers and drinkers. These individuals bring into their bodies the toxic action of ethanol and tobacco smoke. The data obtained show that high alcohol intake causes hypozincemia (less than 10 µmol/L), resulting in hepatic dysfunction, with insufficient vitamin A and folic acid absorption; hepatic and pancreatic dysfunction, with low vitamin C bioavailability; and repression of collagenase enzyme expression. Excessive alcohol consumption and the continual inhalation of tobacco smoke resulted in displacement of zinc homeostasis toward severe hypozincemia (less than 5 µmol/L), alveolar dysfunction with repression of interleukin-10 expression and low vitamin C serological levels. Common pathological events associated with inflammatory processes of the liver, pancreas and alveoli were the excessive production of reactive oxygen species and the manifestation of oxidative stress.


REFERENCES

  1. Prasad AS. Impact of the discovery of human zinc deficiency on health. J Am Coll Nutr. 2009;28:257-65.

  2. Prasad AS. Discovery of human zinc deficiency: 50 years later. J Trace Elem Med Biol. 2012;26:66-9.

  3. Díaz García CM, Álvarez González JL. Aspectos fisiológicos del catión cinc y sus implicaciones cardiovasculares. Rev Cubana Invest Bioméd. 2009 Jun [citado 07 Ago 2014];28(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864- 03002009000200002&lng=es .

  4. Hess SY, Peerson JM, King JC, Brown KH.Use of serum zinc concentration as an indicator of population zinc status. Food Nutr Bull. 2007;28:403S-29S.

  5. Pérez Cantero A. Zinc y rendimiento deportivo. Revista Digital Buenos Aires. 2007 [citado 12 Mar 2012];12(113). Disponible en: http: //www.efedeportes.com

  6. Hambidge KM, Miller LV, Westcott JE, Sheng X, Krebs NF. Zinc bioavailability and homeostasis. Am J Clin Nutr. 2010;91:1478S-83S.

  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington, DC: National Academy Press. 2001:82-109;442-8.

  8. Ikeda M, Ikui A, Komiyama A, Kobayachi D, Tanaka M. Causative factors of taste disorders in the elderly and therapeutic effects of zinc. J Laryngol Otol. 2008;122(2):155-60.

  9. McDaid O, Stewart-Knox B, Parr H, Simpson E. Dietary zinc intake and sex differences in taste acuity in healthy young adults. J Hum Nutr Diet. 2008;20(2):103-10.

  10. Stewart-Knox BJ, Simpson EE, Parr H. Taste acuity in response to zinc supplementation in older Europeans. Br J Nutr. 2008;99(1):129-3.

  11. Hernández Triana M, Porrata Maury C, Jiménez Acosta S, Rodríguez Suárez A, Carrillo Farnés O. Recomendaciones nutricionales para la población cubana, 2008 Estudio multicéntrico. Rev Cubana Invest Bioméd. 2009 Jun [citado 07 Ago 2014];28(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864- 03002009000200001&lng=es .

  12. Cousins RJ. Gastrointestinal factors influencing zinc absorption and homeostasis. Int J Vitam Nutr Res. 2010;80:244-8.

  13. Cao J, Bobo JA, Liuzz JP, Cousins RJ. Effects of intracellular zinc deplection on metallothionein and ZIPS transporter expression and apoptosis. J Leukoc Biol. 2007;70(4):559-66.

  14. Lichten LA, Cousins RJ. Mammalian zinc transporters: nutritional and physiologic regulation. Annu Rev Nutr. 2009;29:153-76.

  15. Hambidge KM, Miller LV, Krebs NF. Physiological requirements for zinc. Int J Vitam Nutr Res. 2011;81:72-8.

  16. Ferrer Arrocha M, Rodríguez Fernández C, González Pedroso MT, Díaz Dehesa MB, Núñez García M. Obesidad, hipertensión y tabaquismo: señales ateroscleróticas tempranas en adolescentes de la secundaria básica "Guido Fuentes". Rev Cubana Invest Bioméd. 2009 Jun [citado 07 Ago 2014];28(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864- 03002009000200006&lng=es .

  17. Pinilla J, González B, Barber P, Santana Y. Smoking in young adolescents: an approach with multilevel discrete choice models. J Epidemiol Community Health. 2002;56:227-32.

  18. Ortiz S, Peña D, Ortiz S, Sánchez R. Consumo de tabaco de los estudiantes de secundaria de Córdoba. Enferm Clínica. 2003;13:154-8.

  19. Wong MM, Klingle RS, Price RK. Alcohol, tobacco, and other drug use among Asian American and Pacific Islander Adolescnts in California and Hawaii. Addict Behav. 2004;29:127-41.

  20. Zapata LB, Forthofer MS, Eaton DK, Brown KM, Bryant CA, Reynolds ST, et al. Cigarette use in 6th through 10th grade: The Sarasota County Demonstration Projet. Am J Health Behav. 2004;28:151-65.

  21. Mowery PD, Farrelly MC, Haviland L, Gable JM, Wells HE. Progression to established smoking among US youth. Am J Public Health. 2004;94:331-7.

  22. Van der Bree MB, Whitmer MD, Pickworth WB. Predictors of smoking development in a populationbased sample of adolescents: a prospective study. J Adolesc Health. 2004;35:172-81.

  23. Zayas Mujica R, Cabrera Cárdenas U, Simón Cayón D. Drogas de abuso. De la embriogénesis a la adolescencia. Rev Cubana Farm. 2006 [citado 14 Mar 2007];40(2). Disponible en: http://bvs.sld.cu/revistas/far/vol40_2_06/far11206.htm

  24. Suárez Lugo N. Paradojas, controversias, discurso y realidad del tabaquismo en Cuba. Rev Cubana Salud Pública [revista en la Internet]. 2011 Mar [citado 2014 Ago 07];37(1). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864- 34662011000100010&lng=es

  25. González Menéndez R. El uso no social de alcohol como factor de riesgo oncológico. Rev Cubana Salud Pública. [citado 07 Ago 2014];37(5). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864- 34662011000500016&lng=es .

  26. Aragón C, Miguel M, Correa M, Sanchis-Segura C. Alcohol y Metabolismo Humano. Adicciones (España). 2002;14(Suppl1):23-42.

  27. Cardellá Rosales L, Hernández Fernández R. Bioquímica Médica. La Habana: ECIMED. 1999;Tomo IV:1259-61.

  28. Krebs NF. Update zinc deficiency and excess in clinical pediatric practice. Ann Nutr Metab. 2013;62 (Suppl 1):19-29.

  29. Manzano Cruz E, Céspedes Miranda E, García Piñeiro JC. Estado antioxidante de daño oxidativo de una población de ancianos de Las Tunas. Rev Cubana Invest Biomed. 2004;23(2):92-7.

  30. Mohammad MK, Zhou Z, Cave M, Barve A, McClain CJ. Zinc and liver disease. Nutr Clin Pract. 2012;27:8-20.

  31. Pitchumoni CS, Rabel NM, Shah R. Factors influencing mortality in acute pancreatitis, can we after then? J Clin Gastroenterol. 2005;39:798-814.

  32. Waugh N, Royle P, Craigie I. Screening for cystic fibrosis-related diabetes: a systematic review. 2012. In: NIHR Health Technology Assessment programme: Executive Summaries. Southampton (UK): NIHR Journals Library; 2003-. Available from: http://www.ncbi.nlm.nih.gov/books/NBK97270/

  33. Malfroot A, Dab I. New insights on gastro-oesophageal reflux in cystic fibrosis by longitudinal follow up. Arch Dis Child. 1991;66(11):1339-45.

  34. Chmiel JF, Konstan MW. Anti-inflammatory medications for cystic fibrosis lung disease: selecting the most appropriate agent. Treat Respir Med. 2005;4(4):255-79.

  35. Abdulhamid I, Beck FW, Millard S, Chen X, Prasad A. Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis. Pediatr Pulmonol. 2008;43:281-7.

  36. Maqbool A, Schall JL, Zemel BS, García-Espana JF, Stallings VA. Plasma zinc and growth status in preadolescent children with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2006;43:95-101.

  37. Barnes PJ, Shapiro SD, Pauwels RA. Enfermedad pulmonar obstructiva crónica: mecanismos moleculares y celulares. Eur Respir J. 2004;5(2):76-95.

  38. Devereux G. ABC of chronic obstructive pulmonary disease. Definition, epidemiology, and risk factors. BMJ. 2006;332:1142-44.

  39. Hess SY, Lonnerdal B, Hotz C, Rivera JA, Brown KH. Recent advances in knowledge of zinc nutrition and human health. Food Nutr Bull. 2009;30(1 Suppl):S5-S11.

  40. González Menéndez R. Epidemiología, Clínica y Terapéutica del Alcoholismo para el Médico de Familia. En: Alcoholismo, Abordaje Integral. Santiago de Cuba: Editorial Oriente; 2004.

  41. De la Cruz Fornaguera Y, Barnes Domínguez JA. Tabaquismo y enfermedad arterial periférica. Revista Cubana de Angiología y Cirugía Vascular. 2013 [citado 13 Mar 2014];14(1). Disponible en: http://bvs.sld.cu/revistas/ang/vol14_1_13/angio05113.htm

  42. Allen C. Es fácil dejar de fumar si sabes cómo. Madrid: Ed. Espasa Calpe; 1996.

  43. Upadhya S, Tirumalai S, Boyd MR, Mont T, Ravindranath Y. Cytochrome P450 2E (CYP2E1) in brain constitutive expression, induction by ethanol and localization by fluorescence in situ hybridation. Arch Biochem Biophys. 2000;373:23-4.

  44. Hu Y, Injelman-Sundberg M, Lindros KO. Induction mechanism of cytochrome P450 2E1 in the liver: Interplay between ethanol treatment and starvation. Biochem Pharmacol. 1995;50:155-65.

  45. Song BJ, Cederbaum AI. Ethanol inductible cytrochrome P450 (CYP2E1). Biochemistry, molecular biology and clinical relevance: 1996 Up date. Alcohol Clin Ex Res. 1996;20:133A-46A.

  46. Mathews CK, Van Holde KE, AhernKG. Biochemistry. 5th ed. San Francisco: Benjamin and Cummings; 2010.

  47. Nelson David L, Cox Michael M. Lehninger: Principios de Bioquímica. 5ª ed. Traductor Claudi M. Cuchillo. Barcelona: Ediciones Omega; 2009.

  48. Thurman RG, Handler JA. New perspectives in catalase-dependent ethanol metabolism. Drug Metab Rev. 1989;20:679-88.

  49. López-Terradas Couise JM. Introducción al estudio de las enfermedades peroximales. Revista de Neurología. 1999;28 (Suppl 1):834-7.

  50. Morón Rodriguez FJ. Farmacología Clínica. La Habana: ECIMED; 2009.

  51. Siles Eva, Martínez Esther. Mecanismos moleculares de la hipoxia. Proyecto del Grupo Estrés Celular y Edad. Universidad de Jaén, Comunidad Autónoma de Andalucía, España. Diario Salud Net. 2013 Oct 3.

  52. Valko M, Leibffritz D, Moncol J, Cronin MT, Mazur M, Tetser J, et al. Free radical and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44-54.

  53. Müller-Esterl W. Bioquímica, Fundamentos para Medicina y Ciencias de la Vida. Barcelona: Editorial Reverté; 2008.

  54. Cáceres Diéguez A. Las vitaminas en la nutrición humana. Santiago de Cuba: Editorial Oriente. 2000:50-5, 71-85.

  55. El Manual de Merck. 11ª ed. Madrid: Editorial Elsevier España S.A. 2007;Tomo I:28-31, 36-8, 58-9.

  56. Lieber CS. Relationships between nutrition, alcohol use, and liver disease. Alcohol Res Health. 2003;27:220-31.

  57. Croft KD, Puddey IB, Rakic V, Abu-Amsha R, Dimmitt SB, Beilin LJ, et al. Oxidative susceptibility of low-density lipoproteins Influence of regular alcohol use. Alcohol Clin Exp Res. 1996;20(6):980-4.

  58. Puddey IB, Croft KD, Abdu-Amsha Caccetta R, Beilin LJ. Alcohol, free radicals and antioxidants. Novartis Found Symp. 1998;216:51-62.

  59. Lugli AK, Carli F, Phil M, Wykes L. The importance of Nutrition Status Assessment: The Case of Severe Acute Pancreatitis. Nutrition Reviews. 2007;85(79):329-34.

  60. Chagoya de Sánchez V, Suárez-Cuenca JA, Hernández-Muñoz R. Nuevo fármaco para el tratamiento de la cirrosis. Gaceta Médica de México. 2007;143(1):44-50.

  61. Cotran RS, Kumar V, Robbins SL. Patología Estructural y Funcional.7ª ed. McGraw-Hill Interamericana de España, S.A. Madrid. 2010:1138-40.

  62. Gisbert Calabuig JA, Villanueva Cañadas E. “Monóxido de carbono”. En: Medicina legal y toxicología. Barcelona: Editorial Masson; 2004.

  63. Ryozo E. Heterogeneous Response Patterns of Alveolar Macrophages from Patients with Lung Cancer by Stimulation with Interferon-γ (en inglés). Japanese Journal of Clinical Oncology. 2000;30:295-300.

  64. Fong KM, Sekido Y, Gazdar AF, Minna JD. Lung cancer. 9: Molecular biology of lung cancer: clinical implications. Thorax (BMJ Publishing Group Ltd.). 2003;58(10):892–900.

  65. Retamales. Amplificatioon of inflammation in emphysema and its association with latent adenoviral infection. Am J Respir Crit Care Med. 2001;164:469-73.

  66. Karahalil B, Hogue BA, De Souza-Pinto NC, Bohr VA. Base excision repair capacity in mitochondria and nuclei: tissue-specific variations. The FASEB Journal. 2002;16:1895-902

  67. Hambidge M, Krebs N. Zinc, diarrea y pulmonía. J Pediatr. 1999;135: 661-4.

  68. Britton JR. Dietary antioxidant vitamin intake and lung function in the general population. Am. J. Respir Crit Care Med. 1995;151:1383-7.

  69. Kimura M, Nishida I, Tofani I, Kojima Y. Effect of calcium and zinc on enchondral ossification in mandibular condyle of growing rats. Dentistry in Japan. 2004;40:106-14.

  70. Traboulsie A, Chemin J, Chevalier M, Quignard F, Nargeot J, Lory P, et al. Subunit-specific modulation of T-type calcium channels by zinc. J Physiol. 2007, 578:159-71.

  71. Ramírez Esteva OE, Cutiño Clavel I, Núñez Bourón AI, Ley López LR. Alteraciones en el metabolismo del calcio y el zinc asociadas a la presencia de daño óseo trabecular. Portales Médicos. 2013 [citado 13 Mar 2014]; VIII(9). Disponible en: http://www.portalesmedicos.com/revista/vol08_n09.htm

  72. Hogg J. Enfermedad pulmonar obstructiva crónica, tabaquismo y cáncer. I Barcelona-Boston Lung Conference, Barcelona; 2014.

  73. Lemus Vidal M, Montero Cruz SA, Cadenas Freixas JL, Luquín de Anda S, García Estrada J, de Álvarez-Buylla RE. Participación del óxido nítrico, proteína Fos y el tallo cerebral en la retención de glucosa encefálica durante la hipoxia. Rev Cubana Invest Bioméd. 2009 Dic [citado 07 Ago 2014];28(4). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864- 03002009000400002&lng=es .

  74. Puig M, Mendieta C. El tabaco: un factor de riesgo en la enfermedad periodontal. Periodoncia. 1998;8(1):241-54.

  75. Sabia S, Elbaz A, Britton A, Bell S, Dugravot A, Shipley M, et al. Alcohol consumption and cognitive decline in early old age. Neurology. 2014 [citado 13 Mar 2014]. Disponible en: www.neurology.org/content/early/2014/01/15/WNL.0000000000000063.abstract?sid =2572be4b-7b61-4a32-9d6d-da1a1d23a899

  76. Aedo F, Delgado R, Wolff D, Vergara C. Copper and zinc as modulators of neuronal excitability in a physiologically significant concentration range. Neurochem Internat. 2007;50:591-600.

  77. Maritzoros CS, Prasad AS, Berck FW, Grabowski S, Kaplan J, Adair C, et al. Zinc may regulate serum leptin concentrations in Humans. J Am Coll Nutrition. 1998;17(3):270-5.

  78. Hallan posible marcador no invasivo para detectar cáncer de pulmón. Clinical Cancer Research; septiembre 2013. doi: 10.1158/1078-0432.CCR-13-0046.).




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