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2015, Number 2

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Rev Med UV 2015; 15 (2)

Leptin biochemical mechanisms involved in the development of obesity

Acosta HME, Ramos MFR, Escobar HJBH, López MJJD, Escobar CP, García RRV, Ortega PCB, Croda-Todd MT, Gasca PE

Language: Spanish
References: 52
Page: 103-113
PDF size: 728.37 Kb.


ABSTRACT

Obesity is characterized by an excessive accumulation of body fat of a higher caloric intake to energy consumption. At the present time it is considered a public health problem worldwide. It is a complex and multifactorial disease, which is developed by different factors, such as genetics, diet, physical inactivity and social conditions. It is now known that the regulation of body weight and body composition depends on the balance between energy intake and energy consumed by the body; these mechanisms are regulated by a bidirectional signaling that occurs between the gastrointestinal (GI) and central nervous system (CNS) through mechanisms acting in the short term and long term, allowing a relatively stable body weight despite daily fluctuations in diet and energy expenditure. One of the proposals to explain the overweight and obesity is an energy imbalance mediated leptin signaling, because leptin controls body fat tissue and, hence, body weight. Some studies showed that exist a strong correlation between serum leptin levels and the percentage of body fat. Deficiency in the production and signaling of this hormone would be related to this pathology. This paper tries to explain the mechanisms of leptin and its relationship with obesity.


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