2015, Number S1
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Rev Med Inst Mex Seguro Soc 2015; 53 (S1)
Fever of unknown origin, comparing two series with 26 years of difference
Casarrubias-Ramírez M, Alfaro-Mejía JA, De Santiago-Leaños J, Mendoza-Álvarez SA, Pineda-Galindo LF, Vera-Lastra OL
Language: Spanish
References: 29
Page: 6-17
PDF size: 182.27 Kb.
ABSTRACT
Introduction: Fever of unknown origin (FUO) remains a syndrome
with difficult approach and changing spectrum.
Our aim was to compare two series of FUO patients seen at the
Department of Internal Medicine, Hospital de Especialidades Centro
Medico La Raza, Mexico City.
Methods: Data from FUO series from 1979-87 were compared with
those from 2004-14 series. We analyzed demographic data, fi nal
diagnoses, and diagnostic tests used. We report median and range
for numerical variables and frequencies for nominal data, bivariate
analysis was done with chi-square or Fisher´s test as needed using
SPSS version 17.0 for MAC and open-epi version 3.7.
Results: One hundred twenty seven patients were included in the
1979-87 series and 118 in the 2004-14 series.
There were more non-infectious inflammatory diseases (
p = 0.0004)
and less infectious diseases (
p = 0.024) in the 2004-14 series. We
observed no significant differences in neoplastic diseases and
undiagnosed cases between the two series. Laboratory tests and
their diagnostic utility were similar in both series, but image studies
were less useful in the 2004-14 series. Biopsy and laparotomy
remained as frequent and useful tools in both series.
Conclusions: The recent series had more non-infectious inflammatory
diseases and less infectious causes of FUO. Invasive
studies remain as useful diagnostic aids in a significant number
of cases.
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