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2016, Number 1

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Investigación en Discapacidad 2016; 5 (1)

Advances in the development of cell therapy for muscular dystrophies

Mondragón-González R, Cisneros VB

Language: Spanish
References: 53
Page: 46-53
PDF size: 211.70 Kb.


ABSTRACT

Muscular dystrophies are genetic diseases characterized by progressive muscular wasting. So far, no therapy is available to cure or ameliorate the course of these pathologies; however, different experimental strategies are currently in development to tackle them. One promising approach involves the transfer of healthy cells to the patient, in order to regenerate muscle tissue. In recent years, different populations of tissue-specific stem cells have been used in cell therapy to fight muscular dystrophies. Recently, the use of embryonic stem cells and induced stem cells has provided promising results in dystrophic murine models. In this review, we recapitulated a series of studies and experimental strategies designed toward the development of an efficient cell therapy against muscular dystrophies.


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