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Federación Mexicana de Ginecología y Obstetricia, A.C.

2005, Number 03

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Ginecol Obstet Mex 2005; 73 (03)

Serum levels of antioxidants and vitamins related to the homocystein's metabolism during postmenopause

López AM, Carmona NLP, Montalvo VI, López DJ, Vital RVS

Language: Spanish
References: 11
Page: 117-123
PDF size: 62.51 Kb.


ABSTRACT

Objective: To describe nutritional status, B6, B12, and antioxidant vitamins, as well as homocysteine concentrations in postmenopausal women.
Patients and methods: A cross-sectional study was conducted in Mexico City. One hundred twenty-five women were selected if they were healthy and were in their first five years after menopause onset. Women were spontaneously divided in two groups: women who did not receive any hormonal treatment for at least six months before the study (n = 66), and those who received hormonal treatment at the moment of the study (n = 59). Anthropometry was measured and a fasting blood sample from a peripheral vein was obtained to determine homocysteine, vitamins A, C, E, B6, B12, and folic acid. Results were compared with Student t-test, and a logistic regression model was used to calculate the risk of hyperhomocystinemia after adjusting by some potential confounders.
Results: Women who did not receive hormone replacement therapy presented higher body mass index and waist-hip ratio than those who received such treatment. In contrast, this group presented higher prevalence of folic acid deficiency and hyperhomocystinemia, despite they consumed higher amounts of folic acid in the diet. This high risk of hyperhomocystinemia was independent of vitamin serum concentrations and the level of physical activity (OR = 15.1, IC95 = 1.60, 141.9).
Conclusions: These results suggest that hormone replacement therapy may protect against overweight and central fat distribution that occur after menopause, but increases the risk of hyperhomocystinemia.


REFERENCES

  1. Rivera-Dommarco J, Shamah-Levy T, Villalpando-Hernández S, et al. Encuesta Nacional de Nutrición 1999. Estado nutricio de niños y mujeres en México. Cuernavaca, Morelos, México. Instituto Nacional de Salud Pública, 2001.

  2. Morris CD, Carson S. Routine vitamin supplementation to prevent cardiovascular disease: a summary of the evidence for the US preventive task force. Clinical Guidelines. Ann Intern Med 2003;139:56-70.

  3. Mosuthapha A, Robinson K. Homocysteine: an emerging age-related cardiovascular risk factor. Geriatrics 1999;54:49-63.

  4. Hernández-Ávila M, Romieu I, Parra S, et al. Validity and reproducibility of a food frequency questionnaire to assess dietary intakes of women living in Mexico City. Salud Publica Mex 1998;40:133-40.

  5. Van der Schow YT, van der Graff Y, Steyerberg EW, Eijkemans JC, Banga JD. Age at menopause as a risk factor for cardiovascular mortality. Lancet 1996;347:714-8.

  6. WHI. Women Health Initiative. Risks and benefits of estrogens plus progestin in healthy postmenopausal women. JAMA 2003;288:321-33.

  7. Hak AE, Polderman KH, Westendorp IC, Jakobs C, Hofman A, Witteman JC, et al. Increased plasma homocysteine after menopause. Atherosclerosis 2000;149:163-8.

  8. Fernandez-Miranda C, de la Calle M, Manuel-Bris J, et al. Influence of menopausal status in homocysteine plasma levels. Med Clin (Barc) 2001;116:206-8.

  9. Strassburg A, Krems C, Luhrmann PM, et al. Effect of age on plasma homocysteine concentrations in young and elderly subjects considering serum vitamin concentrations and different lifestyle factors. Int J Vitam Nutr Res 2004;74:129-36.

  10. Christodoulakos G, Panoulis C, Rizos D, et al. Homocysteine and folate levels in postmenopausal women. Maturitas 2001;39:161-7.

  11. Farag NH, Barshop BA, Mills PJ. Effects of estrogen and psychological stress on plasma homocysteine levels. Fertil Steril 2003;79:256-60.




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