2015, Number 4
<< Back
Acta Med 2015; 13 (4)
Jules Hirsch scientific contributions on the physiopathogeny of obesity and the relationship with the adipose tissue. Eminent pioneer of the meaning of obesity
Zárate A, Manuel L
Language: Spanish
References: 15
Page: 277-280
PDF size: 180.20 Kb.
ABSTRACT
Jules Hirsch was born in New York City and died at age 88 after a long illness. He was considered a notorious leader in the study of human metabolism, mainly in the area of lipids and obesity. His research at The Rockefeller University helped to establish the mechanism of obesity and lipid metabolism. Hirsch joined Rockefeller’s faculty in 1954 and remained there for the rest of his career. Hirsch’s research helped to support the idea of dynamic interactions among diet, physical activity, general metabolism and obesity. At that time, most scientists considered adipose tissue to be biologically inert, a passive insulator in which the body stored energy in the form of triglycerides. Another important contribution was to point out the relationship between diet and cardiovascular ailments, as well as metabolism disturbance. Hirsch had a natural characteristic of showing a nice smile and greeting for everyone he worked with at the university.
REFERENCES
Snyder A. Jules Hirsch. Lancet. 2015; 386: 950.
Bardossi F, Schwartz JN. The fat’s in the fire: [Dr. Jules Hirsch]. Book 23. Rockefeller University Research Profiles; 1985.
Hirsch J, Gallian E. Methods for the determination of adipose cell size in man and animals. J Lipid Res. 1968; 9 (1): 110-119.
Faust IM, Johnson PR, Hirsch J. Non compensation of adipose mass in partially lipectomized mice and rats. Am J Physiol. 1976; 231 (2): 539-544.
Hirsch J, Farquhar JW, Ahrens E, Peterson M, Stoffel W. Studies of adipose tissue in man. Am J Clin Nutr. 1960; 8: 499-511.
Lelliot C, Vidal-Puig AJ. Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. Int J Obes. 2004; 28: S22-S28.
Faust IM, Johnson P, Hirsch J. Role of adipocyte geometry in eating behavior. Science. 1978; 200 (4349): 1505.
Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med. 1995; 332: 621-628.
Hirsch J. Obesity: matter over mind? Cerebrum. 2003; 5: 7-18.
Hirsch J. One thing leads to another. J Clin Invest. 2004; 114: 1040-1043.
Havel PJ. Update on adipocyte hormones. Regulation of energy balance and carbohydrate/lipid metabolism. Diabetes. 2004; 53 (Suppl 1): S143-S151.
Manuel-Apolinar L, Rocha L, Damasio L, Tesoro-Cruz E, Zarate A. Role of prenatal undernutrition in expression serotonin, dopamine and leptin receptors in adult mice: implications of food intake. Mol Med Rep. 2014; 9: 407-412.
Manuel L, Zárate A, Hernández M. La leptina, hormona del adipocito, regula el apetito y el consumo de la energía. Papel en la obesidad y dismetabolismo. Acta Med. 2012; 10: 154-157.
Zárate A, Saucedo R, Basurto L, Hernández M. El tratamiento del colesterol alterado en una encrucijada terapéutica. Rev Med Inst Mex Seguro Soc. 2012; 50: 1-4.
Zárate A, Manuel L, Basurto L, De la Chesnaye E, Saldívar I. Colesterol y aterosclerosis. Consideraciones históricas y tratamiento. Arch Cardiol Méx. 2015, In press.