2005, Number 1
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Perinatol Reprod Hum 2005; 19 (1)
Contraceptives implants
Montenegro-Pereira E, Lara-Ricalde R, Velázquez-Ramírez N
Language: Spanish
References: 35
Page: 31-43
PDF size: 143.77 Kb.
ABSTRACT
The objective of this work it is to up date the information about implantable contraceptives. Description: There are three contraceptive implants in clinical practices: Norplant, since 1985, that consists of 6 capsules of polidimethylsiloxane containing levonorgestrel; Jadelle, since 1995, two rods of a mixture of the same polymer and progestin thet Norplant uses, and Implanon, since 1999, a single rod of ethylenevinyl acetate mixed with etonorgestrel; they are inserted subdermaly in the arm, under local anesthesia; they release the progestin at constant rates after the first year and have a life-span of 5 and 3 years, respectively. Both, Norplant and Jadelle make the cervical mucus impenetrable by spermatozoa. Implanon inhibits ovulation. Other implantable contraceptives under research-contain. Nomegestrol (Uniplant) and nestorone (Elcometrin) Conclusions: Implantable contraceptives are some of the most effective methods, only 0.1 pregnancies per 100 women in the first year of use. All of them produce vaginal bleeding disturbances in about 70% of users. Other events observed are weight increase, headache and breast tenderness. The continuation rates are about 90% in the first year of use.
REFERENCES
Williams C. Stancel G. Estrógenos y progesterona. Bases farmacológicas de la terapéutica Goodman y Gilman. 9th Ed. McGraw Hill; 1996, p. 1497-529.
McCauley A, Geller J. Decisions for Norplant programs. Population reports series K 1992; 20: 3-29.
Darney P, Hormonal implants: contraception for a new century. Am J Obstet Gynecol 1994; 170(spot): 1536-46.
Chien Y, Lin S. Optimisation of treatment by applying programable rater controlled drug delivery technology. Clin Pharmacokinet 2002; 41: 1267-99.
Glassier A. Implantable contraceptive for women effectiveness, discontinuation rates, return of fertility and outcome of pregnancies. Contraception 2002; 65: 29-37.
IPPF Medical Bulletin. Progestagen Implants 2000; 34: 1-4.
Mejorando el acceso al cuidado de calidad en planificación familiar. Criterios médicos de elegibilidad para el uso de anticonceptivos. Organización Mundial de la Salud. Ginebra 2003.
Morrell M. Reproductive and metabolic disorders in women with epilepsy. Epilepsia 2003; 44(Suppl. 4): 11-20.
Meckstroth KR, Darney PD. Anticonceptivos implantables. Clin Obstet Ginecol 2000; 4: 741-74.
Chikamata D, Millar S. Health Services at the clinic level and implantable contraceptives for women. Contraception 2002; 65: 97-106.
Norplant Contraceptive Subdermal Implants. Manual for clinicians. The Population Council 1990.
Hatassaka H, Quian S. Implantable contraceptives. Clin Obstet Gynecol 1995; 4: 829-39.
Olsson S, Bakos O, Lindgren P, Odlind V, Wide L. Ovarian function during use of subdermal implants releasing low doses of levonorgestrel. Br J Plann 1990; 16: 88-93.
Álvarez F, Brache V, Faundes A, Tejada A, Thevenin F. Ultrasonographic and endocrine evaluation of ovarian function among Norplant implant users with regular menses. Contraception 1996; 54: 275-9.
Croxatto H. Mechanisms that explain the contraceptive action of progestin implants for women. Contraception 2002; 65: 21-7.
Critchley H, Bailey B, Chack L, Affandi B, Rogers P. lnmunohistochemical sex steroid receptor distribution in endometrium from long term subderma llevonorgestrel users and during the normal cycle. Human Reprod 1993; 8: 1632-9.
Critchley H, Wang H, Kelly R, Gebbie A, Glasier A. Progestin receptor isoforms and prostaglandin dehydrogenase in the endometrium of women using a levonorgestrel releasing intrauterine system. Human Reprod 1998; 13: 1210-7.
French R, Cowam F, Mansour D. lmplantable contraceptives versus other forms of reversible contraceptives. Health Technol Assess 2000; 4: 1-30.
Dorflinger L. Metabolic effects of implantable steroid contraceptives for women. Contraception 2002; 65: 47-62.
Kahn H, Curtis K, Marchbanks P. Effects of inyectable or implantable progestin on1y contraceptives on insulin glucose metabolism and diabetes risk. Diabetes Care 2003; 26: 216-25.
Sivin l. Risks and benefits, advantages and disadvantages of levonorgestrel releasing contraceptive implants. Drug Safety 2003; 26: 303-35.
Hickey M, Arcanges C. Vaginal bleeding disturbances and implantable contraceptives. Contraception 2002; 65: 75-84.
Cheng L, Zhu H, Wang A, Ben F, Chen J and Glasier A. Once a month administration of mifepristone improves bleeding pattems in women using subdermal contraceptive implants releasing levonorgestrel. Human Reproduction 2000; 15(9): 1969-72.
Glasier A, Wang H, Davie J, KeUy R, Hilary O, Critchley H. Administration of an antipropesterone up regulates estrogen receptors in the endometrium of women using Norplant. Fertility and Sterility 2002; 27(2): 366-72.
Curtis K. Safety of implantable contraceptives for women data from observational studies. Contraception 2002; 65: 85-96.
Brache V, Faudes A, Alvarez F, Cochon L. Nonmestrual adverse events during use of implantable contraceptives for women data from clinical trials. Contraception 2002; 65: 63-74.
Frank J. lmplantable contraception. Am J Obst Gynecol 1991; 63: 190
Diaz S. Contraceptive implants and lactation. Contraception 2002; 65: 39-46.
Jordan A. Toxicology of progestogens of implantable contraceptive for women Contraception 2002; 65: 3-8.
Olav M, Frasier l, D’ Arcanges C. Implantable contraceptives for women. Human Reproduction Update 2003; 9(1): 49-59.
Sivin l. Recent developments in contraceptive implants at the Population Council. Contraception 2002; 65: 113-9.
Sivin l, Nash H, Waldman S. Jadelle levonorgestrel rod implants: a summary of scientific data and lessons learned from programmatic experience. New York: Population Council; 2002, p. 1-34.
Cravioto M, Alvarado G, Canto T, Bassol S, Oropeza G, Santos-Yung R y cols. The efficacy, safety and acceptability of contraceptive subdermal implants Norplant and Norplant II. Contraception 1997; 55: 359-67.
Aznar R, Lara R, Lozano M, Reynoso L. Implantes subdérmicos liberadores de levonorgestrel. Ginecol Obstet Mex 1991; 59: 138-40.
Rodríguez M, Lara R, De la Jara J, Torres A, Ahued R. Norplant: experiencia de tres años en el Instituto Nacional de Perinatología. Ginecol Obstet Mex 1999; 67: 385-9.