Corona-de los Santos JC, Adalid-Arellano D, López-Pelcastre L, Domínguez-Hernández M

Language: Spanish
References: 13
Page: 551-558
PDF size: 441.65 Kb.

ABSTRACT

Background: The development of techniques for detection and quantification of cardiac troponins with high sensitivity and specificity, has improved the prognosis. When cardiomyocytes undergo necrosis lose membrane integrity and the cytosolic content is released into the bloodstream at the start of symptoms.
Objective: To determine the sensitivity and specificity between the quantitative and qualitative method of troponin I in patients with ischemic heart disease.
Methods: transversal, analytic, descriptive and observational study; patients with suspected ischemic heart disease in the Specialty Hospital National Medical Center La Raza to the triage test is conducted by adding whole blood to the device so that the cells are separated from plasma by means of a built-in filter. ZAP the sample moves through the capillary channel receiver detectors cardiac troponin I antibodies and IgG conjugated leporida chromatic form complexes.
Results: Both methods with adequate sensitivity and specificity as well as the association of gender, age and time of evolution for the diagnosis and evolution of ischemic heart disease were compared.
Conclusions: Early diagnosis of acute coronary syndromes favored access to timely care, decreased morbidity and proper management of hospital resources.

REFERENCES

1. Tobacman LS. Thin filament-mediated regulation of cardiac contraction. Annu Rev Physiol 1996;58:447-81.

2. Bucher EA, Maisonpierre PC, Konieczny SF, Emerson CP. Expression of the troponin complex genes: transcriptional coactivation during myoblast differentiation and independent control in heart and skeletal muscles. Mol Cell Biol 2008;8:4134-42.

3. Katus HA, Remppis A, Scheffold T, Diederich KW, Kuebler W. Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction. Am J Cardiol 2001;67:1360-7.

4. Voss EM, Sharkey SW, Gernert AE, Murakami MM, Johnston RB, Hsieh CC, et al. Human and canine cardiac troponin T and creatine kinase-MB distribution in normal and disease myocardium. Infarct sizing using serum profiles. Arch Pathol Lab Med 2005;119:799-806.

5. Adams JE, Schechtman KB, Landt Y, Ladenson JH, Jaffe AS. Comparable detection of acute myocardial infarction by creatine kinase MB isoenzyme and cardiac troponin I. Clin Chem 2004;40(7 Pt 1):1291-5.

6. Galán A. Diagnóstico bioquímico de la isquemia coronaria aguda. Med Clin (Barc) 2000;115:671-6.

7. The Joint European Society of Cardiology/American College of Cardiology Committee. Myocardial infarction redefined. A consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J 2000;21:1502-13.

8. Panteghini M. Acute coronary syndrome. Biochemical strategies in the troponin era. Chest 2002; 122:1428-35.

9. Morrow DA, Cannon CP, Rifai N, Frey MJ, Vicari R, Lakkis N, et al. Ability of minor elevations of troponins I and T to predict benefit from an early invasive strategy in patients whith unstable angina and non-ST elevation myocardial infarction. JAMA 2010;286:2405-12.

10. Stiegler H, Fischer Y, Vázquez-Jiménez JF, Graft J, Filzmaier K, Fausten B, et al. Lower cardiac troponin T and I results in heparin-plasma than in serum. Clin Chem 2000;46:1338-44.

11. Morrow DA, Cannon CP, Jesse RL, Newby LK, Ravkilde J, Storrow AB, et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical characteristics and utilization of biochemical markers in acute coronary syndromes. Circulation 2007;115: 356-75.

12. Apple FS. Analytical issues for cardiac troponin. Prog Cardiovasc Dis 2004;47:189-95.

13. Parmacek MS, Solaro RJ. Biology of the troponin complex in cardiac myocites. Prog Cardiovasc Dis 2004;47:159-76.