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Colegio de Medicina Interna de México.

2015, Number 5

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Med Int Mex 2015; 31 (5)

Relationship between glycosyilated hemogloblin and serum levels of vitamin D

Gallegos-Hernández Ó, Escobedo-de la Cruz RC, Dávila-Sosa D, Rubio-Guerra A, Vargas-Ayala G, Huerta-Ramírez S

Language: Spanish
References: 24
Page: 542-550
PDF size: 431.98 Kb.


ABSTRACT

Background: Vitamin D is involved in insulin sensitivity by calcium metabolism and regulating gene expression insulin receptor. Several studies show a correlation between vitamin D deficiency and glucose intolerance, a decrease in insulin secretion.
Objective: To determine the relationship between serum vitamin D levels and glycosylated hemoglobin in patients with diabetes mellitus type 2 (DM2).
Material and methods: Patients with type 2 diabetes assigned to the outpatient clinic of Internal Medicine, General Hospital Ticomán and without DM2 patients were recruited. They were measured: serum 25-hidroxivitamin D, glycated hemoglobin, serum calcium and phosphorus, BUN, creatinine, and serum glucose preprandial.
Results: 60 patients, 30 cases and 30 controls, 37 women (62.8%) and 23 (38.3%) men were included. Mean age 46.8±12.01 years. In the group with DM2: vitamin D levels had a mean of 12.68±6.7 ng/dL. Glycosylated hemoglobin with an average of 11.33±2.43%. The Pearson correlation coefficient for serum vitamin D and glycosylated hemoglobin was r=-0738, with a coefficient of determination r2 of 0.545 (55%), p ‹0.0001. OR=91 (CI 95%, 15.4-529.4); χ2=38.5, p ‹0.0001.
Conclusions: There was statistically significant association between vitamin D levels and DM2 with a value of χ2=38.5, p ‹0.0001. The OR of 91 (CI 95%, 15.4-529.4) translates the presence of vitamin D deficiency confers a risk 91 times greater of DM2.


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