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2015, Number 4

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Rev Mex Patol Clin Med Lab 2015; 62 (4)

Creatinuria predicted from urine density as the denominator of the index of excretion of a substance

Salabarría GJR, Santana PS, Liriano RMR

Language: Spanish
References: 32
Page: 220-229
PDF size: 360.30 Kb.


ABSTRACT

Rationale: Accuracy of the urinary concentration of a substance as predicted from index of excretion IndEx = Csust/OCre critically relies upon OCre: creatinine urinary concentration. OCre can be stocastically approximated from urinary density (D). Objective: To assess clinical and diagnostic usefulness of the urinary concentration of a substance when OCre as predicted from D is used as denominator of IndEx. Material and methods: Values of D, OCre and concentrations Csust of the substance of interest (sust = total proteins, albumin, calcium, magnesium, uric acid) obtained in urine samples collected from children of either sex, with ages between 1-19 years, assisted at the Urine Section, Clinical Laboratory Service, «Juan Manuel Márquez» Pediatric Teaching Hospital (Havana City, Cuba), between 2009-2014, were recovered. = a + b*Dcorrected, with Dcorrected = (D-1)*100 was used as denominator of IndEx. Results: Analytical accuracy (estimated from the slope of method-comparisons straight line) was more than 80% within the range of concentrations of interest of the substance. Frequency of abnormal values was similar to any of the strategies used in calculating urinary excretion of the substance. Conclusions: Use of OCre as predicted from urine density can be an effective strategy for calculating urinary concentration of a substance as an alternative instead of studies currently done with 24 hours-collections.


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