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2015, Number 3

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Rev cubana med 2015; 54 (3)

The sticky platelet syndrome. Important markers of thrombosis in patient with thrombophilia

Castañeda TM, Carballo TTI, Torres YW, Cepero LK, Montero LM, Montero LX, Ricardo RN, Jimenez SM, González HO

Language: Spanish
References: 42
Page: 214-226
PDF size: 165.35 Kb.


ABSTRACT

Introduction: the sticky platelet syndrome is an entity that causes dysfunctions in the aggregation of the platelets characterized by their abnormal increase (platelet hiperaggregability) and tendency to the thrombosis occurrence, illness that causes morbidity and mortality.
Objective: to characterize the behaviour of the sticky platelet syndrome as a thrombus-genesis marker in the patients with thrombophilia and to determine the relationship of this syndrome with this illness appearance and recurrence associated or not to other thrombosis markers.
Methods: the sample consisted of 63 patients treated in the thrombophilia service at "Hermanos Ameijeiras" Hospital and 66 subjects of both genders, younger than 45 years age, supposedly healthy, from the hospital blood bank of from February 2013 to April 2014. As part of thrombophilic profile, the hyper-aggregation platelet tests were studied by light transmission method, antithrombin, protein C and S, and the lupus anticoagulant, using chromogenic and coagulometric studies. Genetic alterations: factor V Leiden and factor II G20210A A (PG20210A) were assessed by polymerase chain reaction.
Results: there are significant differences between the genders in favour of men for the occurrence of thrombosis (X2= 0.512 p = 0.004). White skin colour predominated to develop thrombotic disease, there were more patients with thrombogenic markers and combinations between them to this ethnic group (X2 = 92.5; p = 0.000). The prevalent genetic marker in patients with factor V Leiden was thrombosis. Significant differences (X2 = 18.68; p= 0.002) are showed between the presence of biomarkers and development of thrombotic disease when linking the different thrombogenic markers in patients with thrombosis and in unselected subjects. SPP type I was the most frequent in this study, followed by type III and type II. (OR= 10.5, 7.1 and 2.5).
Conclusions: there are significant differences between the presence of biomarkers and development of thrombotic disease. The sticky platelet syndrome type I was the most frequent in this study.


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