medigraphic.com
ISSN 1561-302X (Print)

2015, Number 3

<< Back Next >>

Rev cubana med 2015; 54 (3)

Year survival of patients with liver metastases as the first cancer manifestation

Senra ALA, Noa PG, Andara RMT

Language: Spanish
References: 20
Page: 202-213
PDF size: 168.96 Kb.


ABSTRACT

Introduction: liver metastases represent an advanced stage of cancer and hence it is associated with poor survival. Some individual variables can affect the survival of these patients.
Objective: determine overall survival and how they influence the detection of primary tumor, the histologic and fitness in the survival of patients in whom liver metastases was presented.
Methods: a descriptive, longitudinal and prospective study was conducted in patients with liver metastases treated at Hermanos Ameijeiras Hospital from January 2010 to June 2013. 60 patients were included. Absolute frequencies, percentages and standard deviation were calculated. Survival curves were used.
Results: the mean age was 59 years, men dominated with 65%. 46.7 % of patients had a physical condition classifiable as performance status grade 0, according to the scale of the Eastern Cooperative Oncology Group (ECOG), followed by Grade 3 with 20 %. The predominant histological type was adenocarcinoma 38.3 %. The location of the most common primary pancreatic tumor was 15 %; the primary tumor was not identified in 28.3 % of cases. The median overall survival was 7.42 weeks. Patients with 2.3 and 4 degrees ECOG score had a shorter survival with 4.0; 3.71 and 7.42 weeks, respectively. They showed worse survival of patients with non-neuroendocrine tumors. Those with primary digestive tract tumor showed longer survival than the rest.
Conclusions: the overall survival in patients with liver metastases and cancer presentation was poor with a mean of 7.42 weeks from the time of diagnosis. They showed worse survival in patients with performance status greater than 1 and those with no neuroendocrine tumor histology. Those with primary tumors from the digestive tract had higher survival than those suffering this disease in any other location. The treatment used was not considered.


REFERENCES

  1. Seymour K, Charnley R. Evidence that metastasis is less common in cirrhotic than normal liver: a systematic review of post-mortem case-control studies. Br J Surg. 1999;86:1237-43.

  2. Pereira-Lima JE, Lichtenfels E, Barbosa FS, Zettler CG, Kulczynski JM. Prevalence study of metastases in cirrhotic livers. Hepatogastroenterology. 2003;50:1490-5.

  3. Washington K. Pathology of primary and secondary liver tumors. En: Clavien PA. Malignant liver tumors. Current and emerging therapies. London: Blackwell Science, Massachusetts; 1999. p.137-49.

  4. Beckingham I, Krige J. Liver tumors. BMJ. 2001;322:477-80.

  5. Penna C. Prise en charge des patients ayant un cancer du foie. Les métastases hépatiques des cancers colo-rectaux. Bull Cancer. 2003;90:79-83.

  6. Penna C, Nordlinger B. Colorectal metastasis (liver and lung). Surg Clin N Am. 2002;82:1075-90.

  7. Bengtsson G, Carlsson G, Hafstrom L, Jonson P. Natural history of patients with untreated liver metastases from colorectal cancer. Am J Surg. 1981;141:586-9.

  8. Stangl R, Altendorf-Hofmann A, Charnley R, Scheele J. Factors influencing the natural history of colorectal liver metastases. Lancet. 1994;343:1405-10.

  9. Butte JM, Jarufe N, Bellolio F. Factores pronósticos de pacientes con metástasis hepáticas de cáncer de colon y recto. Rev Chilena de Cirugía. 2007;59(4):293-8.

  10. Fizazi K, Culine S. Liver metastases from cancer of unknown primary. Bull Cancer. 1998 Jul;85(7):609-17.

  11. Aguilar J. Consideraciones actuales acerca de la Biopsia Hepática. Rev And Pat Digest. 2003;4:211-4.

  12. Senra Armas L, Hernández Torres E, Álvarez Santana R, Rodríguez Silva H, Cand Huerta C, Roca Campañá V. Valor del examen post mortem en pacientes con cáncer de tumor primario oculto. Rev Cubana Med. 2011;50(4):376-89.

  13. Seve P, Sawyer M, Hanson J, Broussolle C, Dumontet C, Mackey JR. The Influence of Comorbidities, Age, and Performance Status on the Prognosis and Treatment of Patients with Metastatic Carcinomas of Unknown Primary Site. Cancer. 2006;106(9):2058-66.

  14. Pouessel D, Thezenas S, Culine S, Becht C, Senesse P, Ychou M. Hepatic metastases from carcinomas of unknown primary site. Gastroenterol Clin Biol. 2005 Dec;29(12):1224-32.

  15. Hemminki K, Riihimäki M, Sundquist K, Hemminki A. Site-specific survival rates for cancer of unknown primary according to location of metastases. Int J Cancer. 2013 Jul;133(1):182-9.

  16. Lazaridis G, Pentheroudakis G, Fountzilas G, Pavlidis N. Liver metastases from cancer of unknown primary (CUPL): a retrospective analysis of presentation, management and prognosis in 49 patients and systematic review of the literature. Cancer Treat Rev. 2008;34(8):693-700.

  17. Culine S, Kramar A, Saghatchian M. Development and validation of a prognostic model to predict the length of survival in patients with carcinomas of an unknown primary site. J Clin Oncol. 2002;20:4679-83.

  18. Nishimori H, Takahashi S, Katsuyuki K, Ennichi D, Kobashi T, Sano K, et al. Cancer of Unknown Primary Site:A Review of 28 Cases and the Efficacy of Cisplatin/Docetaxel Therapy at a Single Institute in Japan. Acta Med Okayama. 2010;64(5):285-91.

  19. Hogan BA, Thornton FJ, Brannigan M, Browne TJ, Pender S, O'Kelly P, et al. Hepatic metastases from an unknown primary neoplasm (UPN): survival, prognostic indicators and value of extensive investigations. Clin Radiol. 2002 Dec;57(12):1073-7.

  20. Shu X, Sundquist K, Sundquist J, Hemminki K. Time trends in incidence, causes of death, and survival of cancer of unknown primary in Sweden. Eur J Cancer Prev. 2012 May;21(3):281-8.




2020     |     www.medigraphic.com