2015, Number 2
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Bol Clin Hosp Infant Edo Son 2015; 32 (2)
Diseño de Estudios Epidemiológicos. II. El Estudio de Casos y Controles: Del Efecto a la Causa
Cruz-Loustaunau D, Álvarez-Hernández G
Language: Spanish
References: 21
Page: 107-116
PDF size: 305.36 Kb.
ABSTRACT
Epidemiological studies are classifiedas observational or experimental, based on exposure assignment done by the
researcher. Appropriate selection of study design to elucidate questions that have been proposed on a problem, is crucial
when designing a research. Case-control studies are analytical and observational studies departing from the effect and
retrospectively identifying exposures. They are apparently easy to design and conduct, however if the subjects that make up
the control group are not properly selected, there is a risk for different biases, which in turn may causespurious conclusions.
By using this design is possible to establish association between an exposure and a health outcomethrough the
estimation of Odds Ratio (OR).Case-control design allows us to identify factors that prevent or facilitate a health-related
event, therefore the information derived of this design can be helpful in making a decision at the individual and at the
population level.
REFERENCES
1.- Snow J. On the mode of communication of cholera. Churchill 1855. En: Snow on cholera, Commonwealth Fund 1936, reimpresión en Hafner Press, 1965.
2.- Cornfield J. A method of estimating comparative rates from clinical data. Application to cancer of the lung, breast and cervix. J Natl Cancer Inst 1951; 11:1269-75.
3.- Doll R, Hill AB. A study of the etiology of carcinoma of the lung. BMJ 1952; 2: 1271-86.
4.- Herbst A, Ulfelder H, Poskancer DC. Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in Young women. N Engl J Med 1971; 284: 878-81.
5.- Schulz KF, Grimes DA. Case-control studies: research in reverse. Lancet 2002; 359: 431-4.
6.- Schlesselman JJ. Case-Control Studies: Design, Conduct, Analysis. New York: Oxford University Press, 1982: 69-104.
7.- Ibrahim M, Shy C. Case Control Studies Epidemiologic Research and Information center 1999 (5):1-4.
8.- Lazcano-Ponce E, Hernández-Ávila M. Estudios epidemiológicos de casos y controles. Fundamento teórico, variantes y aplicaciones. Salud Pública Mex 2001; 43: 135-50.
9.- Mann CJ. Observational research methods. Research design II: cohort, cross sectional and case-control studies. Emerg Med J 2003; 20: 54-60.
10.- Argimon P, Jiménez V. Métodos de investigación clínica y epidemiológica: Estudios de casos y controles. 4ta Edn. Elsevier.2013: 74-85.
11.- Kelsey, J. Whittemore, A. Methods in observational epidemiology. 2nd Oxford UniversityPress, 1996. pp 188-213.
12.- Mietinnen OS. The «case-control study»: valid selection of subjects. J Chronic Dis 1985; 38 (7): 543-8.
13.- Vandenbroucke JP. STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007; 370(9596): 1453-7.
14.- Grimes DA. Compared to what? Finding controls for case control studies. Lancet. 2005; 365: 1429-33.
15.- Xiaomei MA, Buffler PA, Layefsky M, Does MB, Reynolds P. Control Selection Strategies in Case-Control Studies of Childhood Diseases. Am J Epidemiol 2004; 159: 915-21.
16.- Zondervan KT, Cardon LR, Kennedy SH. What makes a good case-control study? Design issues for a complex traits such a endometriosis. Human Reproduction 2002; 17(6): 1415-23.
17.- Szklo M NF. Los diseños básicos de estudios en epidemiología analítica. Epidemiología Intermedia. 3er Edn. Jones & Bartlett Publishers 2012: 25-43.
18.- Gordis L. Epidemiología. 3er Edn. Elsevier; 2005: 159:76.
19.- Salazar ME, Lazcano PE, González LG, Escudero RP, Salmeron CJ, Hernández AM. Case-control study of diabetes, obesity, physical activity and risk of endometrial cancer among Mexican women. Cáncer Causes Control 2000; 11:707-11.
20.- Silva AL. Cultura estadística e investigación científica en el campo de la salud: una mirada crítica. 1er Edn. Ed. Díaz de Santos.1997: 19-39.
21.- Hernández-Ávila M, Salazar-Martínez E. Sesgos en estudios epidemiológicos. Salud Pública Mex 2000; 42: 438-46.