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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2015, Number 3

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Rev Biomed 2015; 26 (3)

False-negative in the determination of proteinuria in patients of General Hospital Cordoba; comparison of methods

González-Garrido JA, Garrido-Llanos S, Olivares- Corichi IM, García-Sánchez JR

Language: Spanish
References: 26
Page: 119-125
PDF size: 322.92 Kb.


ABSTRACT

Introduction. The diabetes and hypertension are the two most important factor in development of Kidney chronic diseases (KCD). According to the World Health Organization one in 10 adults has some degree of CKD. Quantitation of proteinuria is used as a reflection of renal damage in the ERC, which can be modified.
Objective. The purpose of this study was to compare the variation in quantifying proteinuria on dipstick regarding spectrophotometric techniques in patients of General Hospital Córdoba, Veracruz.
Material and Methods. A total of 58 patients was included in the study. Proteinuria was determined using the test strip and techniques Lowry, Bradford and pyrogallol red in URISCAN PRO II, ILAB and Beckman Coulter (DU-650) systems.
Results. Of the 58 patients included in the analysis dipstick proteinuria in 37 positive and 21 negative patients were found, with an average age of 44 years. The main diagnoses were DM and hypertension. Results indicated an increase in the values of proteinuria Lowry 3.41 times, Bradford 1.97 times and 2.68 times to pyrogallol red compared to the values obtained in the dipstick. In addition, 52.4% false negatives were detected.
Conclusion. In this study, we report that the quantification of proteinuria by dipstick does not have the necessary sensitivity in high-risk patients and suggests the need to implement the use of complementary techniques in the assessment of proteinuria.


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