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ISSN 0864-0289 (Print)

2015, Number 3

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Rev Cubana Hematol Inmunol Hemoter 2015; 31 (3)

Effect of sickle cell disease on the quality of life

MartínezTR, García HA, Guerra GEM, Machado AT, Reytor AK

Language: Spanish
References: 19
Page: 277-287
PDF size: 154.92 Kb.


ABSTRACT

Introduction: sickle cell disease (SCD) is chronic and inherited. It is characterized by chronic anemia and several disorders related to vasoocclusion process. Its severity is variable and the evolution can affect the psychosocial development of the patients. SCD is the most frequent hemolytic anemia genetically determined in Cuba and the incidence of hemoglobin S is 3.08 %.
Objective: To determine the health related quality of life (HRQoL) in SCD adult patients attending the Institute of Hematology and Immunology.
Methods: SF-36 questionnaire was administered to 492 subjects, 187 of them with SCD, ages between 16 and 75 years old. Their results were compared to 183 healthy subjects, 74 hemophiliacs and 48 women with menorrhagia. The reliability and validity of the SF-36 was analyzed.
Results: patients with SCD scored significantly worse than healthy people and better than reports from other countries for this kind of patients. Men with SCD scored different to hemophiliacs in physical functioning and role-physical scales. Women with SCD scored different compared to menorrhagiacs. In physical function, social function, mental health and vitality. The test did not distinguish among different genotypes of SCD. The Cronbach´s index obtained in the scales of SCD patients were higher than 0.70, except for social function (0.67).
Conclusions: patients with SCD have a poor health related quality of life. In this study the SF-36 showed reliability and acceptable discriminant validity.


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