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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2015, Number 3

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An Med Asoc Med Hosp ABC 2015; 60 (3)

Prevalence of congenital heart diseases associated with Down’s syndrome in a population of Mexico City

Espinola ZN, Soto ME, Gómez PLC, Hernández PG, Lupi HE

Language: Spanish
References: 20
Page: 171-176
PDF size: 308.89 Kb.


ABSTRACT

Introduction: Down’s syndrome is a genetic anomaly with increased morbidity and mortality when associated with a congenital heart disease. The aim of this study was to determine the prevalence of congenital heart disease in Down´s syndrome in Mexico City (altitude: 2,240 meters). Method: One hundred twenty-seven patients with Down’s syndrome living in Mexico City were evaluated by physical exam, electrocardiogram and echocardiogram. Results: Congenital heart disease was found in 40%. Patients with congenital heart disease and pulmonary hypertension were classified as having 1) No shunt (n = 18) with systolic pulmonary artery hypertension of 37 ± 9 mmHg; 2) With shunt (n = 33) with systolic pulmonary artery hypertension of 57 ± 29 mmHg (p ≤ 0.001). In those without congenital heart disease or with congenital heart disease without shunt (n = 76), systolic pulmonary artery hypertension was 37 ± 19 mmHg. Conclusion: Down’s syndrome has a high prevalence of congenital heart disease and pulmonary hypertension. Echocardiography is an indispensible tool for evaluation of Down’s syndrome.


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