2001, Number 4
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Vet Mex 2001; 32 (4)
Physiopathology of copper deficiencies in ruminants and its diagnosis
Quiroz-Rochac GF, Bouda J
Language: English/Spanish
References: 59
Page: 289-296
PDF size: 59.72 Kb.
ABSTRACT
Copper (Cu) is an essential element in animal nutrition. There are different clinical signs associated to Cu deficiencies in ruminants. Diagnosis of Cu deficiencies in ruminants is based on blood plasma- or hepatic concentrations of this trace element. However, determining Cu in the liver is technically difficult. Another method for assessing hypocuprosis is the determination of ceruloplasmin (Cp) in plasma. Updated concepts about Cu deficiency diagnosis in ruminants are described. Research should be directed towards new diagnosis methods for hypocuprosis.
REFERENCES
1. Radostits OM, Blood DC, Gay CC. Veterinary medicine. 8th ed. London (UK): Bailliêre Tindall, 1994.
2. Gooneratne SR, Buckley WT, Christensen DA. Review of copper deficiency and metabolism in ruminants. Can J Anim Sci 1989;69:819-845.
3. Graham TW. Trace element deficiencies in cattle. Vet Clin North Am: Food Anim Pract 1991;7:153-215.
4. Gay CC, Pritchett LC, Madson W. Copper deficiency in cattle: a review. Proceedings of the 20th Annual Meeting of the American Association of Bovine Practitioners; 1988 September 18-21; Kansas City (Ka). Rome (Ge): American Association of Bovine Practitioners, 1988:134-138.
5. Ávila GJ, Bouda J, Quiroz RGF, Yabuta OA. Impacto de deficiencias minerales sobre la reproducción de vacas lecheras. Memorias del XXI Congreso Nacional de Buiatría; 1997 julio 9-12; Colima (Col). México (DF): Asociación Mexicana de Médicos Veterinarios Especialistas en Bovinos, A.C., 1997:191-193.
6. Mulryan G, Mason J. Assessment of liver copper status in cattle from plasma copper and plasma copper enzymes. Ann Rech Vet 1992;23:233-238.
7.Vermunt JJ, West DM. Predicting copper status in beef cattle using serum copper concentrations. NZ Vet J 1994;42:142-143.
8. Suttle NF, McMurray CH. Use of erythrocyte copper:zinc superoxide dismutase activity and hair or fleece copper concentrations in the diagnosis of hypocuprosis in ruminants. Res Vet Sci 1983;35:47-52.
9. Kincaid RL, Gay CC, Krieger RI. Relationship of serum and plasma copper and ceruloplasmin concentrations of cattle and the effects of whole blood sample storage. Am J Vet Res 1986;47:1157-1159.
Quiroz RGF. Empleo de las concentraciones de cobre y ceruloplasmina plasmáticas para el diagnóstico de deficiencias de cobre en rumiantes (tesis de maestría). México (DF) México: Facultad de Medicina Veterinaria y Zootecnia. UNAM, 2001.
Smith BP. Large animal internal medicine. St Louis (Mo): Mosby, 1990.
Howard Jl. Current veterinary therapy 3. Food animal practice. Philadelphia: W.B. Saunders Co., 1993.
Grace N. Managing trace element deficiencies. New Zealand: AgResearch, New Zealand Pastoral Agriculture Research Institute Ltd., 1994.
Keen CL, Graham TW. Trace elements. In: Kaneko JJ, editor. Clinical biochemistry of domestic animals. 4th ed. San Diego (Ca): Academic Press, 1989.
Church DC. Fundamentos de nutrición y alimentación de animales. México (DF): UTEHA–Noriega editores, 1994.
Wikse SE, Herd D, Field R, Holland P. Diagnosis of copper deficiency in cattle. J Am Vet Med Assoc 1992;200:1625-1629.
Clark RG, Ellison RS. Mineral testing - the approach depends on what you want to find out. NZ Vet J 1993;41:98-100.
Bouda J, Paasch ML, Yabuta OA. Desarrollo y empleo de diagnóstico preventivo de los trastornos ruminales y metabólicos en bovinos. Vet Méx 1997;28:189-195.
Herrera C. Bioquímica. 2ª ed. Vol II. México (DF): McGraw Hill-Interamericana, 1991.
Swenson MJ, Reece WO. Duke’s physiology of domestic animals. 11th ed. New York: Comstoch Publications Assoc., 1993.
Sanders DE, Sanders JA. Diagnosis and management of copper deficiency in dairy cattle. Mod Vet Pract 1983;64:613-616.
Underwood EJ. Trace elements in human and animal nutrition. 4th ed. New York: Academic Press, 1977.
Dalley DE. Within herd variability in the mineral status of grazing dairy cows in early lactation. Proc NZ Soc Anim Prod 1994;54:27-30.
Ward JD, Spears JW, Kegley EB. Bioavailability of copper proteinate and copper carbonate relative to copper sulfate in cattle. J Dairy Sci 1996;79:127-132.
Suttle NF. Copper deficiency in ruminants; recent developments. Vet Rec 1986;119:519-522.
Smart ME, Christensen DA. The effect of cows dietary copper intake, sire breed, age on her copper status and that of her fetus in the first ninety days of gestation. Can J Comp Med 1985;49:156-158.
Ward JD, Spears JW, Gengelbach GP. Differences in copper status and copper metabolism among Angus, Simmental and Charolais cattle. J Anim Sci 1995;73:571-577.
Du Z, Hemken RW, Harmon RJ. Copper metabolism of Holstein and Jersey cows and heifers fed diets high in cupric sulfate or copper proteinate. J Dairy Sci 1996;79:1873-1880.
Underwood EJ. Los minerales en la nutrición del ganado. 2ª ed. Zaragoza, España: Acribia, 1983.
Suttle NF. The role of comparative pathology in the study of copper and cobalt deficiencies in ruminants. J Comp Pathol 1988;99:241-257.
National Research Council. Nutrient requirements of dairy cattle. Sixth revised edition, update 1989-1988. Washington (DC): National Academy Press, 1987.
Loeb FW, Quimby WF. The clinical chemistry of laboratory animals. 2nd ed. Philadelphia: Taylor & Francis, 1999.
Bremner I, Young BW. Effects of dietary molybdenum and sulphur on the distribution of copper in plasma and kidneys of sheep. Br J Nutr 1978;39:325-336.
Mertz W, Davis GK. Copper. In: Mertz W, editor. Trace elements in human and animal nutrition. Vol I. 5th ed. Philadelphia: Academic Press, 1987.
Ingraham RH, Kappel LC, Morgan EB, Srikandakumar A. Correlation of subnormal fertility with copper and magnesium supplementation. J Dairy Sci 1987;70:167-180.
Aiello SE. The Merck veterinary manual. 8th ed. Whitehouse Station (NJ): Merck & Co. Inc., 1998.
Gengelbach GP, Ward JD, Spears JW, Brown TT. Effects of copper deficiency and copper deficiency coupled with high dietary iron or molybdenum on phagocytic cell function and response of calves to a respiratory disease challenge. J Anim Sci 1997;75:1112-1118.
Faye B, Grillet C, Tessema A, Kamil M. Copper deficiency in ruminants in the Rift Valley of East Africa. Trop Anim Health Prod 1991;23:172-180.
Lofstedt J, Jakowski R, Sharko P. Ataxia, arthritis, and encephalitis in a goat herd. J Am Vet Med Assoc 1988;193:1295-1298.
Unanian MM, Silva AEDF. Studies associating malnutrition with abortion in goats in the northeastern region of Brazil. Pesq Agropec Bras 1989;24:1221-1228.
da Silva MS, Hubinger TC, Döbereiner J. Deficiências e desequilíbrios de microelementos em bovinos e ovinos em algumas regióes do Brasil. Pesq Vet Bras 1999;19:19-33.
Tanner DQ, Stednick JD, Leininger WC. Minimal herd sample size for determination of blood copper status of cattle. J Am Vet Med Assoc 1988;192:1074-1076.
Mills CF. Biochemical and physiological indicators of mineral status in animals: copper, cobalt and zinc. J Anim Sci 1987;65:1702-1711.
Ramírez CE, Ferrer CG. Influencia de diferentes fuentes de variación sobre la concentración plasmática de Cu y Zn en bovinos de tambo. Rev Med Vet 1991;72:16-18.
Suttle NF. Problems in the diagnosis and anticipation of trace element deficiencies in grazing livestock. Vet Rec 1986;119:148-152.
Badiei K. Comparative measurement of copper in different anatomical locations of liver in goats. Proceedings of the 10th International Conference of Production Diseases in Farm Animals; 1998 August 24-28; Utrecht, The Netherlands. Amsterdam, The Netherlands: European Society of Animal Production, 1998.
Mills CF, Dalgarno AC, Wenham G. Biochemic and pathological changes in tissues of Friesian cattle during the experimental induction of copper deficiency. Br J Nutr 1976;35:309-330.
Burtis CA, Ashwood ER. Tietz textbook of clinical chemistry. 2nd ed. Philadelphia: W.B. Saunders Co., 1994.
Evans GW, Wiederanders RE. Blood copper variation among species. Am J Physiol 1967;213:1183-1185.
Telfer SB, Mackenzie AM, Illingworth DV, Jackson DW. The use of caeruloplasmin activities and plasma copper concentrations as indicators of copper status in cattle. Proceedings of the XIX World Buiatrics Congress; 1996 July 8-12; Edinburgh (UK). Edinburgh (UK): British Cattle Veterinary Association, 1996:402-404.
Lenningher LA. Bioquímica. 2ª ed. Barcelona, España: Ediciones Omega S.A., 1991.
The Perkin Elmer Company. Analytical methods for atomic absorption spectrometry. Norwalk (Ct): Perkin Elmer, 1994.
Henry RJ, Canon DC, Winkelman JW. Clinical chemistry, principles and technics. London (UK): Harper & Row, 1974.
Blincoe C. Computer simulation of bovine copper metabolism. J Agric Sci 1993;121:91-96.
Mason J. Thiomolybdates: mediators of molybdenum toxicity and enzyme inhibitors. Toxicology 1986;42:99-109.
Lannon B, Mason J. The inhibition of bovine ceruloplasmin oxidase activity by thiomolybdates in vivo and in vitro: a reversible interaction. J Inorg Biochem 1986;26:107-110.
Mason J, Lamand M, Kelleher CA. The effects of duodenal infusion of tri- and dithiomolybdate on plasma copper and on the diamine oxidase activity of caeruloplasmin (EC1.16.3.1) in sheep. J Comp Pathol 1982;92:509-518.
Sharma AK, Parihar NS. Clinicopathology of induced molybdenum toxicity in young goats. Indian J Anim Sci 1994;64:120-125.
Phillippo M, Humphries WR, Atkinson T. The effect of dietary molybdenum and iron on copper status, puberty, fertility and oestrous cycles in cattle. J Agric Sci 1987;109:321-336.