medigraphic.com
ISSN 1028-4796 (Print)

2015, Number 1

<< Back Next >>

Rev Cubana Plant Med 2015; 20 (1)

Colorrectal cancer chemopreventive properties of Passiflora mollissima (Kunth) L. H. Bailey (banana passion fruit)

Chaparro RDC, Maldonado CME, Urango MLA, Rojano BA

Language: Spanish
References: 34
Page: 62-74
PDF size: 153.06 Kb.


ABSTRACT

Introduction: Passiflora mollissima (Kunth) L. H. Bailey (banana passion fruit), a fruit that contains polyphenolic compounds and high reducing capacity, with few information about their benefits on the prevention of colorectal cancer.
Objectives: evaluate the effect of regular consumption of curuba in the prevention of Colorectal Cancer in a preclinical experimental model induced with azoxymethane.
Methods: chemopreventive activity of banana passion fruit was estimated counting Aberrant Crypt Foci in the colon of mice when the fruit was administered before and after the induction of colon cancer with the agent azoxymethane. The total phenols, flavonoids and carotenoids content was determined by spectrophotometric methods. The antioxidant capacity by FRAP (Ferric Reducing/Antioxidant Power) DPPH and ORAC (oxygen radical absorbance capacity) methods.
Results: banana passion fruit regular ingesting has dose-dependent effect on the reduction of Aberrant Crypt Foci in the studied model in vivo. The phenol content was: 460.1 mg. Gallic acid/100g dried fruit; the flavonoid content: 1907.6mg Catechin/100 g of dried fruit, and carotenoid content: 118.8 mg β-caroteno/100 g dried fruit. FRAP value: 8520.31 mg equivalent/100 g ascorbic acid, DPPH 60843.11 µmol Trolox Equivalent/100g dried fruit, ORAC 20962.60 µmol Trolox/100g dried fruit.
Conclusions: banana passion fruit has phenolic and carotenoid compounds, presents antioxidant capacity, and reduces the formation of Aberrant Crypt Foci.


REFERENCES

  1. Internacional Agency for Research on Cancer .GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. [database on the Internet] Francia. [updated 2014; cited 2014 Apr 9]. Available from: http://globocan.iarc.fr/Default.aspx

  2. Carethers JM. Systemic treatment of advanced colorectal cancer: Tailoring therapy to the tumor. Ther Adv Gastroenterol. 2008;1:33-42.

  3. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nature Rev. 2003;3:768-780.

  4. Amin R, Kucuk O, Khuri FR, Shin DM. Perspectives for cancer prevention with natural compounds. J Clin oncol. 2009;27:2712-25.

  5. Béliveau R, Gingras D. Role of nutrition in preventing cancer. Can Fam Phys. 2007;53:1905-11.

  6. Marshall JR. Prevention of colorectal cancer: diet, chemoprevention and lifestyle. Gastroenterol Clin North Am. 2008:73-83.

  7. Karikas GA. Chemoprevention molecular and biochemical mechanisms involved in cancer control and management. Health science journal. 2011;5(2):8

  8. Contreras J, Calderón L, Guerra E, García B. Antioxidant capacity, phenolic content and vitamin C in pulp, peel and seed from 24 exotic fruits from Colombia. Food research international. 2011;44(11):2047-53.

  9. Botero ML, Ricaurte SC, Monsalve CE, Rojano BA. Capacidad reductora de 15 frutas tropicales. Scientia Et Technica. 2007;13(33):295-6.

  10. Vasco C, Ruales J, Kamal-Eldin A. Total phenolic compounds and antioxidant capacities of major fruits from Ecuador. Food Chem. 2008;111(4):816-23.

  11. Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdicphosphotungstic acid reagents. American J Enology Viticulture. 1965;16:144-58.

  12. Naranjo M, Vélez T, Rojano B. Actividad antioxidante de café colombiano de diferentes calidades. Rev Cubana Plant Med. 2011;16(2):164-73.

  13. Debnath T, Park P, Debnath N, Samad NB, Park HW, Lim BO. Antioxidant activity of Gardenia jasminoides Ellis fruit extracts. Food Chem. 2011;128(3):697- 703.

  14. Biswas AK, Sahoo J, Chatli MK. A simple UV-Vis spectrophotometric method for determination of β-carotene content in raw carrot, sweet potato and supplemented chicken meat nuggets. Food Sci Technol. 2011(44):1809-13.

  15. Mercado G, De La Rosa L, Wall A, Lopéz JA, Álvarez E. Compuestos polifenólicos y capacidad antioxidante de especias típicas consumidas en México. Nutr Hosp. 2013;28(1):36-46.

  16. Kuskoski ME, Asuero AG, Troncoso AM, Mancini-Filho J, Fett R. Aplicación de diversos métodos químicos para determinar actividad antioxidante en pulpa de frutos. Ciência e Tecnologia de Alimentos. 2005;25(4):726-32.

  17. Brand-Williams W, Cuvelier ME, Berset C. Use of a free radical method to evaluate antioxidant activity. Lebensmittel Wissenchaft und Technologie. 1995;28(1):25-30.

  18. Benzie IFF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of ‘‘Antioxidant Power’’: the FRAP assay. Anal Biochem. 1996;239(1):70-6.

  19. Prior RL, Wu X, Schaich K. Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. Journal Agr Food Chem. 2005; 53(10):4290-302.

  20. Romero M, Rojano B, Mella J, Pessoa CD, Lissi E, López C. Antioxidant capacity of pure compounds and complex mixtures evaluated by the ORAC-Pyrogallol Red Assay in the Presence of Triton X-100 Micelles. Molecules. 2010;15(9):6152-67.

  21. Rojano BA, Zapata K, Cortes FB. Capacidad atrapadora de radicales libres de Passiflora mollissima (Kunth) L. H. Bailey (curuba). Rev Cubana Plant Med. 2012;17(4):408-19.

  22. Bird RP. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett. 1987;37:147-51.

  23. Carvajal LM, Turbay S, Rojano B, Álvarez LM, Restrepo SL, Álvarez JM, et al. Algunas especies de Passiflora y su capacidad antioxidante. Rev Cubana Plant Med. 2011;16(4):354-63.

  24. Zegbe JA, Serna A, Mena J. Mineral nutrition enhances yield and affects fruit quality of ‘Cristalina’ cactus pear. Sci Hortic. 2014;167:63-70.

  25. López A, Fenoll J, Helín P, Flores P. Physical characteristics and mineral composition of two pepper cultivars under organic, conventional and soilless cultivation. Sci Hortic. 2013;150:259-66.

  26. Prior RL, Wu XL, Schaich K. Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. J Agric Food Chem. 2005;53(10):4290-302.

  27. Otero L. El cultivo de la curuba. Revista Esso Agrícola. 1988;XLI:11-7.

  28. Soobrattee M A, Bahorun T, Aruom OI. Chemopreventive actions of polyphenolic compounds in cancer. Biofactors. 2006;27:19-35.

  29. Wang SY, Jiao H. Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen. J. Agric. Food Chem. 2000;48:5677-84.

  30. Zhang Y, Seeram P, Lee R, Fend L, Heber D. Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties. J. Agric. Food Chem. 2008;56:670-5.

  31. Elisia I, Kitts DD. Anthocyanins inhibit peroxyl radical induced apoptosis in Caco-2 cells. Mol. Cell. Biochem. 2008;312:139-45.

  32. Schantz M, Mohn C, Baum M, Richling E. Antioxidative efficiency of an anthocyanin rich bilberry extract in the human colon tumour cell lines Caco-2 and HT-29. J. Berry Res. 2010;1:25-33.

  33. Bornsek SM, Lovro Z, Polak T, Vanzo A, Ulrich NP, Abram V, et al. Bilberry and blueberry anthocyanins act as powerful intracellular antioxidants in mammalian cells. Food Chem. 2012;134:1878-84.

  34. Johnson IT. New approaches to the role of diet in the prevention of cancers in the alimentary tract. Mutat. Res. 2004;551:9-28.




2020     |     www.medigraphic.com