2015, Number 3
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Otorrinolaringología 2015; 60 (3)
Efficacy of benzydamine vs placebo in the control of postsurgery sore throat of patients submitted to laryngeal microsurgery
Pintos-Manríquez LM, Akaki-Caballero M, Saavedra-Mendoza AG
Language: Spanish
References: 23
Page: 130-139
PDF size: 561.76 Kb.
ABSTRACT
Background: Postoperative sore throat is a minor complication, primarily caused by injury to the mucosa from oral endotracheal intubation and microlaryngeal surgery. The incidence of postoperative sore throat is 79%. Although in most cases it will resolve spontaneously, prevention focused on reducing its frequency and severity are recommended to better patient satisfaction and quality of postoperative care.
Objective: To compare the efficacy of benzydamine
vs placebo in the control of postoperative sore throat in patients undergoing elective microlaryngeal surgery under general anesthesia and oral endotracheal intubation.
Material and method: A randomized, double-blind controlled clinical trial was done with 18 patients submitted to elective microlaryngeal surgery who were enrolled and randomized in two groups: group A, saline solution and group B, benzydamine. Patients were asked to gargle the solution for 30 seconds 5 minutes before induction of anesthesia. Postoperative sore throat at rest and swallowing were evaluated with a simple verbal scale of 4 points (0-3) during the fist hour and at 6, 12 and 24 hours.
Results: Benzydamine consistently reduced postoperative sore throat at rest and swallowing; however, only postoperative sore throat at rest at 6 hours showed a 50% reduction with a significant difference (p=0.043).
Conclusions: there is a statistically significant difference in the prevention of postoperative sore throat at rest at 6 hours for patients submitted to laryngeal microsurgery with the benzydamine gargle previous to anesthetic induction, compared to placebo.
REFERENCES
Fried M, Ferlito A. The larynx. 3rd ed. Plural Publishing, 2009.
Klussmann JP, Knoedgen R, Damm M, Wittekindt C, Eckel HE. Complications of suspension laryngoscopy. Ann Otol Rhinol Laryngol 2002;111:972-976.
Müller A, Verges L, Schleier P, Wohlfarth M, Gottschall R. The incidence of microlaryngoscopy associated complications. HNO 2002;50:1057-1061.
Rosen CA, Andrade PA, Scheffel L, Buckmire R. Oropharyngeal complications of suspension laryngoscopy: a prospective study. Laryngoscope 2005;115:1681-1684.
Mohamad H, Mohamad I. Tongue paraesthesia and dysgeusia post suspension laryngoscopy. Kobe J Med Sci 2012;58:60-62.
Corvo MA, Inacio A, Mello MB, Eckley CA. Extra-laryngeal complications of suspension laryngoscopy. Braz J Otorhinolaryngol 2007;73:727-732.
Fang R, Chen H, Sun J. Analysis of pressure applied during microlaryngoscopy Eur Arch Otorhinolaryngol 2012;269:1471-1476.
Jung H, Kim HJ. Dexamethasone contributes to the patient management after ambulatory laryngeal microsurgery by reducing sore throat. Eur Arch Otorhinolaryngol 2013;270:3115-3119.
Hu B, Bao R, Wang X, Liu S, Tao T, et al. The size of endotracheal tube and sore throat after surgery: a systematic review and meta-analysis. PLoS One 2013;8:74467.
Turnbull RS. Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions. J Can Dent Assoc 1995;61:127-134.
Gulhas N, Canpolat H, Cicek M, Yologlu S, et al. Dexpanthenol pastille and benzydamine hydrochloride spray for the prevention of post-operative sore throat. Acta Anaesthesiol Scand 2007;51:239-243.
Mazzarella B, Macarone Palmieri A, Mastronardi P, Spatola R, et al. Benzydamine for the prevention of pharyngolaryngeal pathology following tracheal intubation. Int J Tissue React 1987;9:121-129.
Kati I, Tekin M, Silay E, Huseyinoglu UA, Yildiz H. Does benzydamine hydrochloride applied preemptively reduce sore throat due to laryngeal mask airway? Anesth Analg 2004;99:710-712.
Agarwal A, Nath SS, Goswami D, Gupta D, et al. An evaluation of the efficacy of aspirin and benzydamine hydrochloride gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study. Anesth Analg 2006;103:1001-1003.
Hung NK, et al . Effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine. Anesth Analg 2010;111:882-886.
Huang YS, et al. The effectiveness of benzydamine hydrochloride spraying on the endotracheal tube cuff or oral mucosa for postoperative sore throat. Anesth Analg 2010;111:887-891.
Hara K, Maruyama K. Effect of additives in lidocaine spray on postoperative sore throat, hoarseness and dysphagia after total intravenous anaesthesia. Acta Anaesthesiol Scand 2005;49:463-467.
Honma K, Kamachi M, Akamatsu Y, Yoshioka M, Yamashita N. Lidocaine spray 10 min prior to intubation: effects on postoperative sore throat. J Anesth 2010;24:962-965.
Soltani HA, Aghadavoudi O. The effect of different lidocaine application methods on postoperative cough and sore throat. J Clin Anesth 2002;14:15-18.
McHardy FE, Chung F. Postoperative sore throat: cause, prevention and treatment. Anaesthesia 1999;54:444-453.
Kawahara S, Hara K, et al. Laryngotracheal application of lidocaine spray increases the incidence of postoperative sore throat after total intravenous anesthesia. J Anesth 2004;18:237-240.
Hara K, Maruyama K. Effect of additives in lidocaine spray on postoperative sore throat, hoarseness and dysphagia after total intravenous anaesthesia. Acta Anaesthesiol Scand 2005;49:463-467.
Tanaka Y, Nakayama T. Lidocaine for preventing postoperative sore throat. Cochrane Database Syst Rev 2009;3:4081.