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2000, Number 3

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Rev Inst Nal Enf Resp Mex 2000; 13 (3)

Pulmonary metastases of soft tissue sarcoma. Eleven years of experience at the National Cancerology Institute.

Hernández-Rodríguez NA, Correa E, Contreras-Paredes A, Green L

Language: Spanish
References: 33
Page: 133-138
PDF size: 171.84 Kb.


ABSTRACT

Background. Although soft tissue sarcomas are rare tumors, they induce pulmonary metastases in up to 70% of cases. The frequency and distribution of pulmonary metastases in the Mexican population with this type of sarcoma have not been documented and the present study describes these variables in patients from the National Cancerology Institute. Methods. A retrospective analysis was performed, between 1986 and 1996, reviewing charts from patients with diagnosis of soft tissue sarcoma. Information was collected on demographic data, tumor histology and the subsequent development of pulmonary metastases. Results. A total of 247 patients were included. Pulmonary metastases developed in 69 (28%) of patients. Patients were 111 (45%) males and 136 (55%) females, with a median age of 35 years. Regarding tumor histology we found 73 (30%) liposarcomas, 13 (18%) with pulmonary metastases; 61 (35%) synovial sarcomas, 28 (45%) with metastases and 31 (12%) rhabdomyosarcomas, 11 (35%) with metastases. Considering the date of admittance medians of up to 24 months of metastases development were observed. Patients with synovial sarcoma, angiosarcoma and liposarcoma showed survival of less than 20% after 60 months, which is significantly lower than that observed in patients without pulmonary metastases (p=0.0006, p=0.038 and p=0.01 respectively). Conclusions. A frequency of 28% of sarcoma patients developed pulmonary metastases. Synovial sarcoma, angiosarcoma and rhabdomyosarcoma were main inducers of pulmonary metastases.


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