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2015, Number 3

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Gac Med Mex 2015; 151 (3)

Sclerosing acral skin perineurioma: clinicopathologic study of ten cases (eight classical and two with xanthomatous changes)

Toussaint-Caire S, Aguilar-Donis A, Torres-Guerrero E, Asz-Sigall D, Vega-Memije ME, Lacy-Niebla RM, Domínguez-Cherit J, Alfaro LP, Ortiz-Hidalgo C

Language: Spanish
References: 28
Page: 299-305
PDF size: 340.80 Kb.


ABSTRACT

Introduction: Perineurioma is an infrequent and benign cutaneous neoplasm characterized by proliferation of perineurial cells. It is classified into two main types: intraneural and the extraneural or soft tissue perineurioma, in which the sclerosing variant is included. Sclerosing perineurioma is more frequently found on acral skin. Clinically, they are well-circumscribed, skin colored, nodular tumors. Objective: Describe and communicate clinicopathologic findings from a case series of sclerosing acral perineurioma. Material and Methods: This is a clinical, morphological and immunohistologic case study of eight patients with the diagnosis of sclerosing perineurioma. Results: It included five men and five women, with ages ranging between nine and 66 years. All of them had lesion on acral skin. At microscopy study, the lesions showed a proliferation of epithelioid and spindle-shaped perineurial cells, arranged in small aggregates and short fascicles between thickened collagen bundles. Immunohistochemistry studies revealed that the proliferating cells expressed EMA, Claudin-1 and Glut-1, and were negative for S-100 protein. Conclusions: It is important to report these infrequent skin tumors, so they can be taken into account in the differential diagnoses of acral lesions.


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