2001, Number 2
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Vet Mex 2001; 32 (2)
Feline hepatic idiopathic lipidosis
Koloffon TS, Trigo TFJ, López MA
Language: English/Spanish
References: 40
Page: 109-116
PDF size: 68.54 Kb.
ABSTRACT
A literature review on feline hepatic idiopathic lipidosis is presented. The pathogenesis of this condition in cats has only been partially elucidated, and it is closely related to protein and lipid metabolism; stress and obesity are the two most common involved factors. Clinical signs start with anorexia, progressive weight loss, depression, and hepatomegalia, accompanied by increased serum levels of hepatic enzymes and bilirrubin. Once hepatic lipidosis is clinically diagnosed, complementary exams and laboratory tests must be conducted to rule out other pathologic processes that cause secondary hepatic lipidosis. Once these conditions have been ruled out, the diagnosis of feline hepatic idiopathic lipidosis can be reached.
REFERENCES
1. Dimsky DS, Taboada J, Feline idiopathic hepatic lipidosis. Vet Clin North Am: Small Anim Pract 1995;25:357-371.
2. Barsanti JA, Jones BD, Spano JS, Taylor HW. Prolonged anorexia associated with hepatic lipidosis in three cats. Feline Pract 1977;3:52-57.
3. Center SA. Hepatic lipidosis, glucocorticoid hepatopathy, vacuolar hepatopathy, storage disorders, amyloidosis, and iron toxicity. In: Guildford M, editor. Strombeck’s small animal gastroenterology. 3rd ed. New York: W.B. Saunders, 1996:766-801.
4. Biourge V. Sequential findings in cats with hepatic lipidosis. Feline Pract 1993;21:25-28.
5. Biourge VC, Groff JM, Munn RJ, Kirk CDA, Thomas GN, Madeiros VA. Experimental induction of hepatic lipidosis in cats. Am J Vet Res 1994;55:1291-1302.
6. Griffin B. Feline hepatic lipidosis: pathophysiology, clinical signs, and diagnosis. Comp Cont Educ Pract Vet 2000;22:847-858.
7. Golden M, Ramdath D. Free radicals in the pathogenesis of Kwashiorkor. Proc Nutr Soc 1987;46:53-68.
8. Riggs CM. Idiophatic feline hepatic lipidosis. Feline Pract 1991;19:12-15.
9. Dimsky DS. Feline hepatic lipidosis. Sem Vet Med Surgery (Small Anim) 1997;12:28-33.
Baker DH, Czarnecki-Maulden GL. Comparative nutrition of cats and dogs. Ann Rev Nutr 1991;11:239-257.
Zawie DA, Garvey MS. Feline hepatic disease. Symposium on advances in medicine II. Vet Clin North Am: Small Anim Pract 1984;14:1201-1235.
12 Hubbard BS, Vulgamott JC. Feline hepatic lipidosis. Cont Educ Feline Focus 1992;14:459-464.
Center SA, Warner K. Feline hepatic lipidosis: better defining the syndrome and its management. Proceedings of the 16th Forum of the ACVIM; 1998 May 31; San Diego (Ca). Lakewood (Ca): American College of Veterinary Internal Medicine, 1998:56-58.
Thornburg L, Simpson S, Digilio K. Fatty liver syndrome in cats. J Anim Hosp Assoc 1982;18:397-400.
Cotran R. Robbins pathologic bases of disease. 4th ed. New York: W.B. Saunders, 1989.
Hall JA, Barstad LA, Connor WE. Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis. J Vet Int Med 1997;11:238-242.
Rebouche CJ, Engel AG. Carnitine metabolism and deficiency syndromes. Mayo Clin Proc 1983;58:533-540.
Jacobs G, Cornelius L, Keene B, Rakich P, Shug A. Comparison of plasma, liver, and skeletal muscle carnitine concentrations in cats with idiopathic hepatic lipidosis and healthy cats. Am J Vet Res 1990;51:1349-1351.
Jacobs G, Cornelius L, Allen S, Greene C. Treatment of idiopathic hepatic lipidosis in cats: 11 cases (1986-1987). J Am Vet Med Assoc 1989;195:635-638.
Center SA. Pathophysiology of liver disease: normal and abnormal function. In: Guildford M, editor. Strombeck’s small animal gastroenterology. 3rd ed. New York: W.B. Saunders, 1996:550-578.
Mannaerts GP, Debeer LJ. Mitochondrial and paroxysmal b-oxidation of fatty acids in rat liver. Ann NY Acad Sci 1982;386:30-39.
Center SA, Guida L, Zanelli MJ, Dougherty E, Cummings J, King J. Ultraescultural hepatocellular features associated with severe hepatic lipidosis in cats. Am J Vet Res 1993;54:724-731.
Pazak HE, Bartes JW, Cornelius LC, Scott MA, Gross K, Huber TL. Characterisation of serum lipoprotein profiles of healthy, adult cats and idiopathic feline hepatic lipidosis patients. J Nutr 1998;128:2747-2750.
Johnson S. Disease of the liver. In: Ettinger SJ, Feldman EC, editors. Veterinary internal medicine. Toronto, Canada: W.B. Saunders, 1994:1261-1357.
Maclachlan NJ, Cullen JM. Liver, billiard system, and exocrine pancreas. In: Carlton W, McGavin M, Zachary JF, editors. Thomson’s special veterinary pathology. 3rd ed. St Louis (Mo): Mosby, 2000:81-115.
Kelly WR. The liver and billiard system. In: Jubb KVF, Kennedy PC, Palmer N, editors. Pathology of domestic animals. New York: Academic Press, 1993:239-312.
Jones TC, Hunt DR, King NW. Veterinary pathology. Philadelphia: Williams and Wilkins, 1997.
Center SA, Thompson M, Wood PA, Millington DS, Chace DH. Hepatic ultrastructural and metabolic derangements in cats with severe hepatic lipidosis. Proceedings of the 9th Forum of ACVIM; 1991 May 30; New Orleans (Lo). Lakewood (Ca): American College of Veterinary Internal Medicine, 1991:87-90.
Harry DS, Owen JS, McIntyre N. Lipids, lipoproteins and cell membranes. Prog Liver Dis 1982;7:319-329.
Yeager AE, Mohammed H. Accuracy of ultrasonography in the detection of severe hepatic lipidosis in cats. Am J Vet Res 1992;53:597-599.
Biourge V, Massta B, Groff JM, Morris JG, Rogers QR. Effects of protein, lipid or carbohydrate supplementation on hepatic lipid accumulation during rapid weight loss in obese cats. Am J Vet Res 1994;55:1406-1415.
Smith CA. Changes and challenges in feline nutrition. J Am Vet Med Assoc 1993;203:1395-1400.
Center SA. Nutritional support for dogs and cats with hepatobiliary disease. J Nutr 1998;128(Suppl 12):27335-27455.
Frank A, Feinstein RE. Hepatic lipidosis associated with severe vitamin B12 deficiency recognised by liver Cobalt status in three cats. Feline Pract 1991;19:16-20.
Roger QR, Morris JG, Freedland RA. Lack of hepatic enzymatic adaptation to low and high levels of dietary protein in the adult cat. Enzyme 1977;22:348-356.
Center S. A retrospective study of 77 cats with severe hepatic lipidosis: 1975-1990. J Vet Int Med 1993;6:349-359.
Biourge V. Spontaneous occurrence of hepatic lipidosis in a group of laboratory cat. J Vet Int Med 1993;3:194-197.
Alpers DH, Sabesin SM. Fatty liver: biochemical and clinical aspects. In: Schiff L, Schiff E, editors. Diseases of the liver. 6th ed. New York: J.B. Lippincott, 1987:949-978.
Herdt T. Fisiología gastrointestinal/metabolismo. En: Cunningham JG, editor. Fisiología veterinaria. México (DF): Interamericana-McGraw-Hill, 1994:277-315.
Akol KG, Washabau RJ, Saunders HM, Hendrick MJ. Acute pancreatitis in cats with hepatic lipidosis. J Vet Int Med 1993;7:205-209.