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2014, Number 4

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Rev Cubana Invest Bioméd 2014; 33 (4)

Calcium creatinine ratio in the diagnosis of hypercalciuria in gallstone pediatric population

Bacallao MRA, Badell MA, Gutiérrez GF, Mañalich CR, Madrid MCF, López ML

Language: Spanish
References: 17
Page: 410-418
PDF size: 252.64 Kb.


ABSTRACT

Introduction: hypercalciuria is the main metabolic disorder in urolithiasis. Diagnosis involves collecting urine for 24 hours with risk of errors and calcium creatinine ratio has been used as a marker of hypercalciuria.
Objectives: determine the validity of this indicator as a hypercalciuria marker.
Methods: a cross-sectional descriptive study was conducted due to the importance of the diagnosis of hypercalciuria and disagreements on the utility of calcium creatinine ratio and optimal cutoff. 1603 Cuban lithiasic subjects were studied. Their age ranged between 2 and 19 years. 24 hour urinary calcium and calcium- creatinine ratio of the second morning urine were studied.
Results: moderate positive correlation between variables was obtained. For values of traditional cutting of calcium creatinine ratio, sensitivity was 95.7% and 81.9%, and specificity 48.3% and 66.7% for children and adolescents, respectively.
Conclusions: calcium creatinine ratio is useful as evidence of population screening for hypercalciuria, however for diagnostic confirmation the measurement of urinary calcium is inevitably required by collecting urine for 24 hours.


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