Silveira NM, Razia GL, Martini R, Filipini RR, Locatelli A, Hörner M, Hörner R

Language: Portugués
References: 18
Page: 573-581
PDF size: 127.40 Kb.

ABSTRACT

Introduction: several studies have revealed that the increase of bacterial resistance to antibiotic is really alarming in the last few years. Consequently, the discovery of new active substances is a must and the triazene compounds appear as a promising class of metal drugs with significant antimicrobial action. On the other hand, the association of radical pharmacophorous triazene with metals such as gold facilitates the production of greater biological action molecules.
Objective: to evaluate the in vitro antibacterial activity of this unprecedented compound called gold complexed with triazene at oxidation state I {(1-(2-bromophenyl)-3-(2-nitrophenyl)triazenide(triphenylphosphane)gold(I)} against the bacterial standard strains, American Type Culture Collection reference strains and the multiple drug resistance clinical isolates.
Methods: the antibacterial activity of the compound triazene was estimated by the minimal inhibitory concentration method on the basis of the clinical and laboratory standards 2012. This method is visually characterized as the lowest concentration that fully inhibited the bacterial growth in the dilution wells.
Results: the tested compound showed significant antibacterial activity, being active in 43.4 % (10/23) of tested bacteria and selective for Gram-positive strains.
Conclusions: triazene complex showed narrow action spectrum since it is only active against Gram-positive microorganisms, which is in turn an alternative for conception of a new class of metal drugs with antibacterial action.

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