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2001, Number 1

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Vet Mex 2001; 32 (1)

Evaluation of chemotherapeutic models for the control of Fasciola hepatica in cattle in humid warm climate in Mexico

Quiroz RH, Ibarra VF, Ochoa GP, Manga-González MY, Montenegro CM, Salcedo ER

Language: English/Spanish
References: 32
Page: 55-61
PDF size: 53.38 Kb.


ABSTRACT

In order to evaluate 2 models of chemotherapy against Fasciola hepatica in naturally infected cattle located in a farm in the municipality of Nautla in the State of Veracruz in Mexico, triclabendazole (tbz) was administered once or twice in different months to reduce faecal egg output in a significant way. Furthermore, anti- F. hepatica antibody values, as well as seric levels of gamma-glutamyl transpeptidase (ggt) and aspartate amino transferase (ast), were also determined. Two groups (G) of 23 animals each received 12 mg/k of tbz. G-1, the control group, was treated in January, whereas G-2 in January and May. Stool samples were collected from all animals every 45 days during 10 times in order to perform faecal egg count per 5 g (epg). At the same time, blood samples were collected from 15 cows of each group to detect anti- F. hepatica antibodies by the ELISA test, and to determine ggt- and ast enzymes by spectrophotometry. Improvement percentage for epg was 27.6% higher in G-2 than in G-1; this epg agrees with the lower values of ggt detected in G-2, and ast activity did not exceed the normal limit. Antibody levels were positive, and were not affected by the treatment in any of the groups.


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