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2015, Number 2

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Rev Cuba Endoc 2015; 26 (2)

Clinical and therapeutic factors influencing the achievement of pregnancy among patients undergoing in vitro fertilization

Rodríguez MK, Méndez VJ

Language: Spanish
References: 54
Page: 108-123
PDF size: 194.72 Kb.


ABSTRACT

Introduction: in vitro fertilization is the high technology assisted reproduction method most commonly used in the treatment of infertile patients.
Objective: determine the clinical and therapeutic factors influencing the achievement of pregnancy by in vitro fertilization.
Methods: a retrospective longitudinal cohort study was conducted with 654 infertile couples to determine the influence of a number of factors upon the achievement of pregnancy by in vitro fertilization. The factors considered were maternal age, years of infertility, type of infertility and cause, number of aspirated follicles, endometrial thickness, serum estradiol before the administration of human chorionic gonadotropin, semen quality, basal follicle-stimulating hormone, and treatment with gonadotropin-releasing hormone analogues and its modifications.
Results: 25.10 % of the patients included became pregnant. A statistically significant difference was found between patients becoming and not becoming pregnant as to age (p= 0.001), estradiol concentration (p= 0.003), endometrial thickness (p= 0.001) and aspirated follicles (p= 0.045). Secondary infertility increased the probability of becoming pregnant by 15 %, optimal semen by 47 % and treatment with leuprorelin acetate by 28 %. The multivariate analysis variables most closely related to the achievement of pregnancy were treatment with leuprorelin acetate (p= 0.001), optimal semen (p= 0.028) and endometrial thickness (p= 0.036).
Conclusions: treatment scheme, semen quality and endometrial thickness are independent factors influencing the achievement of pregnancy in patients undergoing in vitro fertilization.


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