2015, Number 2
Modified chromogenic method to assess anti-Xa activity in jaundiced patients
García-de Paoletti DN, Paoletti ME, Paoletti EA, Aloni-Risana E, Soto JG, Barassi CA, Pereyra MA, Cerviño MF, Suárez-González L, Mielgo D
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Language: English
References: 7
Page: 121-127
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ABSTRACT
Objective: To propose a modification of the chromogenic conventional method (Rorachrom Heparin Stago’s Method) to be used in patients with jaundice.Material and method: An analytic epidemiological study was made. We compared the values of anti-Xa activity in 40 patients with jaundice and without jaundice using a modified chromogenic conventional method. The Pearson coefficient correlation was calculated.
Results: The absorbance of each reading was concurrent with the concentration of low molecular weight heparin added in each tube is not modified by the value of bilirubin with the pNA. The adaptation mentioned could be used in jaundice newborn achieving a more exact measurement of blood level of heparin.
Conclusions: The modified chromogenic conventional method is an excellent tool to have into consideration to measure anti-Xa in patients with jaundice.
REFERENCES
Greaves M. Control of Anticoagulation Subcommittee of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis. Limitations of the laboratory monitoring of heparin therapy. Scientific and Standardization Committee Communications: on behalf of the Control of Anticoagulation Subcommittee of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis. Thromb Haemost. 2002;87:163-164.