medigraphic.com

2015, Number S2

<< Back Next >>

Rev Mex Anest 2015; 38 (S2)

Coagulopathy secondary to trauma

Carrillo-Esper R, Zepeda-Mendoza AD, Carrillo-Córdova DM, García de Alba-Graue P, Carrillo-Córdova CA

Language: Spanish
References: 15
Page: 392-396
PDF size: 195.18 Kb.


ABSTRACT

Trauma-induced coagulopathy has a multifactorial aetiology. It is related to blood loss including consumption of clotting factors and platelets and haemodilution. Additionally inflammation, endotelial damage, hyperfibrinolysis, hypothermia, acidosis and metabolic changes affect the coagulation system. Treatment of trauma-induced coagulopathy may be based on systemic antifibrinolytics, local haemostatics and individualized point-of-care guided rational use of coagulation factor concentrates such as fibrinogen, prothrombin complex concentrate and fibrinogen concentrate.


REFERENCES

  1. Writin D, Di Nardo JA. TEG y ROTEM: technology and clinical applications. Am J Hematol. 2014;89:228-232.

  2. Nardi G, Agostini V, Rondinelli B, Russo B, et al. Trauma induced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs. Crit Care. 2015;19:817-820.

  3. Levi M. Disseminated intravascular coagulation. Crit Care Med. 2007;35:2191-2195.

  4. Dunbar NM, Chandler WL. Thrombin generation in trauma patients. Transfusion. 2009;49:2652-2660.

  5. Chandler WL. Procoagulant activity in trauma patients. Am J Clin Pathol. 2010;134:90-96.

  6. Maegele M, Schol H, Cohen MJ. An up-date on the coagulopathy of trauma. Shock. 2014;41:21-25.

  7. Castellheim A, Brekkle OL, Espevik T, Harboe M, Mollnes TE. Innate inmune responses to danger signals in systemic inflammatory response syndrome and sepsis. Scand J Immunol. 2009;69:479-491.

  8. Esmon CT, Xu J, Lupu F. Innate immunity and coagulation. J Thromb Haemost. 2011;9:182-188.

  9. Sorensen B, Fries D. Emerging treatment strategies for trauma-induced coagulopathy. Br J Surg. 2012;99:40-50.

  10. Tauber H, Innerhofer P, Breitkopf R. Prevalence and impact of abnormal ROTEM assays in severe blunt trauma: results of the diagnosis and treatment of trauma induced coagulopathy (DIA-TRE-TIC) study. Br J Anaesth. 2011;107:378-387.

  11. Kaibara M, Iwata H, Ujiie H. Rheological analyses of coagulation of blood from different individuals with special reference to procoagulant activity of erythrocytes. Blood Coagul Fibrinolysis. 2005;16:355-363

  12. Schochl H, Nienaber U, Hofer G, Voelckel W, Jambor C, et al. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care. 2010;14:R55.

  13. Shakur H, Roberts I, Bautista R, Caballero J, Coats T, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomized, placebo-controlled trial. Lancet. 2010;376:23-32.

  14. Hippala ST, Myllyla GJ, Vahtera EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg. 1995;81:360-365.

  15. Fenger-Erickson C, Lindberg-Larsen M, Christensen AQ, Ingerslev J. Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentration. Br J Anaesth. 2008;101:769-773.




2020     |     www.medigraphic.com