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2002, Number 1

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Rev Mex Patol Clin Med Lab 2002; 49 (1)

Bone age: desintometric and metabolic estimation

Terrés-Speziale AM, Tamayo OJA, Valle SOA

Language: Spanish
References: 33
Page: 7-14
PDF size: 324.29 Kb.


ABSTRACT

Chronobiology is the science that measures biologic phenomena through biostatistical methods in order to determinate the presence of biological rhythms and cycles with the fundamental purpose to quantify biological variability. Objective: Statistical chronobiological correlation of somatometric data, densitometry, and urinary calcium and creatinine, through female life span, to establish reference limits and clinical decision levels for osteoporosis, plus a formula for the calculation of a Bone Metabolic Age Index BMAI. Methods: Clinical, retrospective and observational study, including the statistical management of a clinical data base, of a dedicated, specialized clinic for the study, prevention and management of bone metabolic diseases. Results: From 3,250 medical charts, 1,117 cases were selected after accomplishing the protocol’s criteria. Patients had an age of 55 ± 12 years, 1.50 ± 0.10 m, 62.9 ± 11.3 kg. Body mass index BMI 26 ± 2 kg/m2 had a progressive improvement until 65 years (r = 0.97). Urinary calcium and creatinine had a wide variability through the decades (CV = 83% on both cases) while the ratio CaU/CrU had a CV = 47% (0.17 ± 0.08). Bone Mass Density BMD measured through T-Score descended progressively through life span while CaU/CrU rose with coefficients of correlation of -0.92 and 0.96 respectively. Inferential statistical analysis of somatometry, CaO/CrO and BMD with polynomic curves and multiple regressions plots evolved to establish BMAI. Conclusion: Chronobiology is a new approach in the understanding of health and disease. Chronobiological simultaneous approach of these three parameters is not only useful on the diagnosis of the osteopenic and osteoporotic condition, since it may also be useful to establish the index that we named Bone Metabolic Age. Hypothesis that at present is clinically under evaluation.


REFERENCES

  1. Tamayo J. How frequent is osteoporosis? Journal of Bone and Mineral Research 1997.

  2. XI Censo General de Población y Vivienda, 1990. México. INEGI, 1991-1998.

  3. Encuesta nacional sobre la sociodemográfica del envejecimiento, 1994. México. INEGI, 1995.

  4. Encuesta Nacional de Empleo, 1990. Informe único, México. INEGI, 199O.

  5. Programa Nacional de la Mujer, 1996. México. Secretaría de Gobernación, 1996.

  6. Alianza en favor de la mujer del Distrito Federal, 1998. Informe único, México. Gobierno del Distrito Federal, 1998.

  7. Halberg F. Chronobiology. Ann Rev Physiol 1969; 31: 675-725.

  8. Ahlgren A, Halberg F. Cycles of nature: an introduction to biological rhythms. National Science Teachers Association, Washington, D.C., 1990, 87 pp.

  9. Aréchiga H. Circadian rhythms. Current opinion in neurobiology 1993; 3: 1005-1010.

  10. Sánchez de la Peña S. The feed sideward of cephaloadrenal immune interactions. Chronobiology 1993; 20: 1-52.

  11. Halberg F. Quo vadis basic and clinical Chronobiology. Am J Anat 1983; 168: 543-594.

  12. Sánchez de la Peña S. Conceptos básicos en cronobiomedicina. Rev Med IMSS 1996; 132(4): 123-135.

  13. Portela A: Cronobiología en medicina y cirugía. Gac Méd Méx 1996; 132(4): 409-423.

  14. Smolensky MH. Chronobiology and Chronotherapeutics. Applications to Cardiovascular Medicine. Am J Hypertension 1996; 9: 11-21.

  15. Arendt J. Biological Rhythms: The Science of Chronobiology. JR Coll Physicians Lond 1998; 32: 27-35.

  16. Soler A. Perfil de edad biológica en una población laboral. Geriatrika 1990; 6: 17-21.

  17. Iguchi A. Assessment of biological age and indices of aging. Nippon Ronen 1996; 33: 806-810.

  18. Touitou Y. Chronobiological approach of aging. Pathol Biol 1996; 44: 534-546.

  19. Dean W. Biological aging measurement. Geronto Geriatrics 1998; 1: 64-85.

  20. IFCC Expert panel on theory of reference values. Part 1. The concept of reference values. Clin Chem 1979; 25: 1506.

  21. IFCC Expert panel on theory of reference values. Part 5. Statistical treatment of collected reference values. Determination of reference limits. J Clin Chem Clin Biochem 1982; 20: 841.

  22. IFCC Expert panel on theory of reference values. Part 6. Presentation of observed values related to reference values. J Clin Chem Clin Biochem 1983; 21: 749.

  23. Barnett RN. Clinical laboratory statistics. Boston USA: Little Brown & Co, 1971.

  24. Statland BE. Clinical decision levels for laboratory tests. NJ USA: Medical Economic Books. 1983.

  25. Winkel P, Statland BE. Interpreting laboratory results: reference values and decision making. In: J Bernard Henry. Clinical Diagnosis & Management by Laboratory Methods. 18th edition. Philadelphia: WB Saunders Company, 1991.

  26. Terrés-Speziale AM. Influencia de la edad en los valores de referencia del antígeno específico de la próstata en población mexicana. Rev Mex Patol Clin 1998; 45: 85-95.

  27. Terrés-Speziale AM, Alcántara GLE. Glicemia. Liímites de Referencia Biocronológicos y Niveles de Decisión Clínica. Rev Mex Patol Clin 1999; 46: 133-143.

  28. Terrés-Speziale AM, Martínez ME. Cronobiología: niveles hormonales en mujeres mexicanas. Rev Med IMSS 2000; 37(5): 341-348.

  29. Terrés-Speziale AM, Razo MD. Fórmula roja: límites de referencia biocronológicos y niveles de decisión clínica. Rev Med IMSS 2000; 38(4): 313-321.

  30. Terrés SAM. Marcadores biológicos de envejecimiento. Rev Mex Patol Clin 2000; 47(2): 119-120.

  31. 31.Terrés-Speziale AM. El laboratorio clínico y la evaluación del riesgo coronario. Rev Mex Patol Clin 2000; 47(4): 202-218.

  32. Terrés-Speziale AM. Lípidos: aplicación de niveles de decisión clínica. Cronobiología en México. Rev Med IMSS 2001; 39(2): 97-104.

  33. Terrés-Speziale AM. Marcadores biológicos de envejecimiento en el hombre mexicano. Rev Med IMSS 2001; 39(3): 199-206.




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