2001, Number 4
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Rev Mex Patol Clin Med Lab 2001; 48 (4)
The role of the clinical laboratory facing bioterrorism
Barriga AG, Giono CS
Language: Spanish
References: 23
Page: 194-202
PDF size: 128.25 Kb.
ABSTRACT
While the recent growing awareness of the threat of biological weapons affects all segments of the population, the impact on clinical laboratory is more direct. If a bioterrorist event occurred, the average clinical microbiology laboratory could be instrumental in helping to detect and identify the biological weapon that was used and in alerting authorities. Although Bacillus anthracis and smallpox have received a great deal of publicity as potential biological weapons, the term biological agent applies to a diverse group of microorganisms as well as toxins of microorganisms, plants and animals.
This review will trace the origins of biological weapons and describe current perceptions of the threat proposed by the use of such weapons. And the perceived roles of clinical laboratories, the clinical and microbiological aspects of the agents though most likely to be used by bioterrorist will be described.
REFERENCES
Christopher GW, Cieslak TJ, Paulin JA, Eitzen EM. Biological Warfare: a historical perspective. JAMA 1997; 278: 412-417.
Cole LA. The specter of biological weapons. Sci Am 1996; 275: 60-65.
Eickhoff TC. Airborne disease: including chemical and biological warfare. Am J Epidemiol 1996; 144: 539-546.
Poupard JA, Miller LA. History of biological warfare: catapults to capsomeres. Ann NY Acad Sci 1992; 666: 9-20.
Harris S. Japanese biological warfare research on humans: a case study on microbiology and ethics. Ann NY Acad Sci 1992; 666: 21-52.
Davis CJ. Nuclear blindness: an overview of the biological weapons programs of the former Soviet Union and Iraq. Emerg Infect Dis 1999; 5: 509-512.
Meselson M, Guillemin J, Jones HM, Langmuir A, Popuva I, Shelokov A, Yampolskaya O. The Sverdlovsk anthrax outbreak 1979. Science 1994; 266: 1200-1202.
Centers for disease control and prevention and National Institutes of Health. Biosafety in microbiological and biomedical laboratories. 4ª ed. Washington, D.C.: 1999.
Alibeck K, Handelman S. Biohazard: The chilling true story of the largest cover biological weapons program in the world. New York, N. Y.: Random House, 1999.
English JF. Overview of bioterrorism readiness plan: a template for health care facilities. Am J Infect Control 1999; 27: 468-469.
McSweegan E. Hot times for hot labs. ASM News 1999: 65-11, 743-745.
Sewell DL. Laboratory Associated Infections and Biosafety. Clin Microbiol Rev 1995: 8, 3, 389-405.
Henderson DA. Smallpox: Clinical and Epidemiological Features. Emerg Infec Dis 1999: 5, 4, 537-539.
Le Duc JW, Decker J. Current status of smallpox vacine. Emerg Infect Dis 1999; 5, 4, 593-594.
Breman JG, Henderson DA. Pox-virus dilemmas, monkeypox, smallpox, and biologic terrorism. N Engl J Med 1998; 339: 556-559.
Allen SP. Clostridium Manual of Clinical Microbiology. 7th ed. Washington, D.C.: AMS, 1999: 654-671.
Horgen J. Were four corners victims biowar casualties tiej? Sci Am 1993; 269: 16.
Franz DR. Clinical recognition and management of patients exposed to biological warfare agents. JAMA 1997; 278: 399-411.
www.cdc.gov/od/ohs/lrsat/addinfo.htm.
attp//www.cdc.gov/od/ohs/biosfty/biosfty.htm.