Dávila GHL, Álvarez CF, Peña MML, García VA, Matos RZ

Language: Spanish
References: 27
Page: 388-398
PDF size: 138.49 Kb.

ABSTRACT

Introduction: the hypothesis on the possibility that papilloma virus had to do with cervix cancer was first raised in 1975. Today we know that this virus is also responsible for malignancies throughout the lower genital tract.
Objective: characterize the behavior of epithelial lesions of the lower genital tract infections associated with human papilloma virus in the Isle of Youth from 2010 to 2013.
Method: aretrospective study was performed according to variables of interest, 412 patients shaped our sample.
Results: third of the cases occurred in patients aged 40-49 years, 69% of patients had a lesion confined to the cervix, 64% underwent their last Pap smear three years before diagnosis. 74% had low-grade lesions and 58% reported having only one sexual partner in the last 10 years. 41% of cases recognized vaginal discharge as the most common symptom, and colposcopy was the average final diagnostic procedure in 26% of cases.
Conclusions: the largest number of cases occurred during the fifth decade of life. Low-grade cervical lesions, cytology in three years before diagnosis and referred monogamy were predominant findings in our study. Vaginal discharge was the most common symptom and colposcopy as a diagnostic procedure contributed significantly to positive diagnosis.

REFERENCES

1. Gómez Gutiérrez G. Lesiones preinvasoras de cérvix, vulva y vagina. En: Fundamentos de Oncología. Editora Médica Panamericana. México, 2010. p. 337-43.

2. Comino Delgado R, Cararach Tur M, Cortés Bordoy J, Dexeus Trias de Bes S, López García G, Puig-Tintoré LM, et al. Prevención del cáncer de cérvix uterino. En: Documentos de consenso de la SEGO 2006. Madrid: Meditex, 2007:123-78.

3. Somogyi L, Malpica Gracián CC, Alvarado B, García M. Virus del papiloma humano (VPH) detección y tipificación en la consulta privada. Rev Obstet Ginecol Venez.2010;70(3):160-6.

4. Dawar M, Deeks S, Dobson S. Human papillomavirus vaccines launch a new era in cervical cancer prevention.CMAJ.2007;177(1):456-60.

5. Castellsague X. Natural history and epidemiology of HPV infection and cervical cancer. Gynecol Oncol.2008;110(1):4-7.

6. Sherris J. Prevención del Cáncer Cervical en las comunidades de escasos recursos. Outlook.2010;18(1):1-8.

7. Woodman C. Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study.Lancet.2011;357(9):1831-6.

8. Jayshree RS, Sreenivas A, Tessy M, Krishna S. Cell intrinsic & extrinsic factors in cervical carcinogenesis. J Med Res.2009;13(2):286-95.

9. Gay Pereyra E. Neoplasia intraepitelial vulvar. Archivos Médicos de Actualización en Tracto Genital Inferior.2011;3(4):15-34.

10. Sarduy Nápoles M. Correlación citohistológica en las neoplasias intraepiteliales cervicales y en la identificación del VPH en esas lesiones. Rev Cub Obstet Ginecol.2009;35(1):2-7.

11. Milián Vega F, Fernández J, Rodríguez R, Rodríguez T. Estudio de algunos factores epidemiológicos en pacientes con citologías anormales. Rev Cub Obstet Ginecol. 1999;25(3):181-9.

12. Martínez V, Torriente B. Neoplasia cervical en la mujer climatérica. Rev Cub Obstet Ginecol. 2006;32(1):12-4.

13. MINSAP. Dirección Nacional de Estadísticas. Anuario Estadístico 2011.

14. Bosch FX, Lorincz A, Muñoz N, Meijer CJLM, Shah KV. The casual relation between human papillomavirus and cervical cancer. J Clin Pathol.2002;31(1):3-13.

15. Wieland U, Pfister H. Papillomavirus in human pathology: Epidemiology, pathogenesis and oncogenic role. Chapter 1. En: Gross G, Barrasso R. Human Papilloma Virus Infection. Alemania: Editorial Ullstein Mosby.1997. p. 1-6.

16. Muñoz N: Human papillomavirus and cancer: the epidemiological evidence. J Clin Virol.2000;19(1):1-5.

17. Serra I. Auditoría de muertes por cáncer cervicouterino, Servicio de Salud Metropolitano Sur-Oriente, 2005. Análisis preliminar. Rev Med Chile.2007;26(2):1010-8.

18. Diestro Tejeda MD, Serrano Velasco M, Gómez-Pastrana Nieto F. Cáncer de cuello uterino. Estado actual de las vacunas frente al virus del papiloma humano (VPH). Oncología.2007;30(2):123-67.

19. Garnett TO, Duerksen-Hughes PJ: Modulation of apoptosis by human papillomavirus (HPV) oncoproteins. Arch Virol.2006;151(3):2321–35.

20. Castaño P, Pelayo A, Millana C, Gallardo CK, Vidart MA, Herraiz MA, Fariña J. Detección del HPV en lesiones epiteliales del aparato genital femenino mediante PCR. [Citado 20 de agosto de 2012] Disponible on-line: http://www.conganat.org/3congreso/cvhap/conferencias/009/texto.htm

21. Staff A, Wilkinson EJ, Mattingly RF. Laser treatment of cervical and vaginal neoplasia. Am J Obstet Gynecol.2007;128(6):128-36.

22. Goldstein MA, Goodman A, del Carmen MG, Wilbur DC. Case records of the Massachusetts General Hospital. A 23-year-old woman with an abnormal Papanicolaou smear. N Engl J Med. 2009;360(13):1337–4.

23. Rivera R, Aguilera J, Larraín A. Epidemiología del virus papiloma humano (HPV). Rev Chil Obstet Ginecol 2002; 67(6):501-6.

24. Wieland U, Pfister H. Papillomavirus in human pathology: Epidemiology, pathogenesis and oncogenic role. Chapter 1. En: Gross G, Barrasso R. Human Papilloma Virus Infection. Alemania: Editorial Ullstein Mosby; 1997. p.1-6.

25. León Cruz G, Bosques Diego O, Silveira Pablos M, De la Torre AI, Soto P, Rodríguez V. Incidencia de los factores de riesgo en mujeres cubanas con diagnóstico de lesiones oncológicas de cérvix. 20009[Citado 14 de abril del 2009]; 48(1).Disponible on-line:http://www.bvs.sld.cu/revistas/med/vol4 8_09/med06109.htm

26. Giard R. False-Negative Rate of Cervical Cytology: sense and sensitivity. Diagn Cytopathol.2007;25(5):275-7.

27. Castrillo Cárdenas KG, Morales Arias JL. Lesiones intraepiteliales de bajo grado. Rev Médica Costa Rica y Centroamérica.2010;59(1):43-50.