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2015, Number 2

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Rev Mex Patol Clin Med Lab 2015; 62 (2)

Immune response to Helicobacteri pylori

Cervantes GE, García-González R

Language: Spanish
References: 57
Page: 112-118
PDF size: 301.98 Kb.


ABSTRACT

The host response against H. pylori infection is ineffective in eliminating the bacteria. The innate immune system plays a central role in processing and displaying antigens from H. pylori. Regulatory cytokines (IL-10 and IL-12) might regulate a T-lymphocyte (Th) response type 1, leading to chronic gastritis or Th-2 response with antibody production and bacterial eradication, across IFN-g, response Th-1, might regulate the induction and expression of human leukocyte antigen-II (HLA-II) in epithelial cells, increasing H. pylori adherence to gastric epithelium. The response Th-2 by production IL-4 might increase the expression of HLA-II, IgG, IgE, viability and stimulation of T-cell growth.


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