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2014, Number 3

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Biotecnol Apl 2014; 31 (3)

Evolutionary, physiological and biotechnological aspects of ferrochelatase and heme in higher plants

Ortega-Rodés P, Grimm B, Ortega E

Language: English
References: 105
Page: 176-186
PDF size: 407.05 Kb.


ABSTRACT

Heme, is a cofactor for essential proteins, it is synthesized after the insertion of Fe2+ into protoporphyrin ring by the ferrochelatase (FC) enzyme. Although FC is well described, there are still major questions about the regulation of the heme biosynthetic pathway, and the localization of the enzyme in plants. This review provides a comprehensive survey of research on function and the metabolism of heme in plants including the unique properties of the plant heme metabolism. We will summarize the knowledge of the expression, reaction mechanism, localization and the phylogeny of FC. Increasing the heme iron content in plant foods is a biotechnological challenge to improve the dietary intake of iron in the population; it is known that heme-contained iron is absorbed 5-10- times higher than non-heme iron. In this review we suggest potential biotechnological modifications of plant heme metabolism for increasing the capacity of crop plants to resist abiotic and biotic stress, thus improving food and fodder plants as source of dietary iron.


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