2015, Number 04
<< Back Next >>
Ginecol Obstet Mex 2015; 83 (04)
Cervix adenocarcinoma in a virgin patient with negative human papillomavirus
González-Ballano I, Aragón-Sanz MA, Guardia-Dodorico L, Rojas Pérez-Ezquerra B
Language: Spanish
References: 13
Page: 240-246
PDF size: 711.45 Kb.
ABSTRACT
Cervical cancer in virgin women is extremely rare. We present the case
of a 36-year-old patient without any type of sexual contact with sensation
of lump in external genitalia referring only irregular bleeding in
the previous two months, finding in vaginal examination an indurated
mass in vaginal introitus with result in the biopsy of adenosquamous
adenocarcinoma. The evolution of the tumor was very aggressive in spite
of trying palliative chemotherapy, and patient died two months after of
diagnosis with lung, liver and brain metastases. Cervical human papillomavirus
testing was negative. What unusual of these cases does not
justify the cytology as the only method of screening for cervical cancer.
REFERENCES
Bosch FX, Manos MM, Muñoz N, Sherman M, et al. Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective. International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst 1995;87:796-802.
Walboomers J, Jacobs M, Manos M, Bosch X, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189:12-19.
Böhmer G, Van den Brule AJ, Brummer O, Meijer CL, Petry KU. No confirmed case of human papillomavirus DNA-negative cervical intraepithelial neoplasia grade 3 or invasive primary cancer of the uterine cervix among 511 patients. Am J Obstet Gynecol 2003;189(1):118-20.
Liu S, Semenciw R, Mao Y. Cervical cancer: the increasing incidence of adenocarcinoma and adenosquamous carcinoma in younger women. CMAJ 2001;164:1151-1152.
Gottwald L, Korczynski J, Gora E, Kusinska R, et al. Clear cell adenocarcinoma of the uterine cervix in a 24-year-old woman. Case report and review of the literature. Arch Med Sci 2012;8(3):578-581.
Lanzón Lacruz R, Ruiz Conde MA, Lanzón Laga A. Cáncer invasor de cuello uterino. En: Tratado de ginecología, obstetricia y medicina de la reproducción. 2ª ed. Madrid: Editorial Médica Panamericana, 2003;1559-1577.
Lee YL, Chang KH, Kyung M, Kim H, Park S. A case of clear cell adenocarcinoma in the uterine cervix of 52-year-old virgin. Korean J Obstet Gynecol 2012;55(3):192-196.
Sahoo T, Dhal I, Padhy A, Majumdar S, Parida D. Primary clear cell adenocarcinoma of uterine cervix in a young woman without history of diethylstilbestrol exposure: a case report and a review of literature. Int J Sci Study 2014;8:198-200.
Liebrich C, Brummer O, Von Wasielewsk R, Wegener G, et al. Primary cervical cancer truly negative for high-risk human papillomavirus is a rare but distinct entity that can affect virgins and young adolescents. Eur J Gynaec Oncol 2009;3:45-48.
Pestana I, Costa A, Gorgal R, Mota R, et al. Cervical uterine cancer in a virgin young woman, case report. J Obstet Gynaecol 2014:1-2.
Yabushita H, Kanyama K, Sekiya R, Noguchi M, Wakatsuki A. Clear-cell adenocarcinoma of the uterine cervix in a 17-year-old adolescent. Int J Clin Oncol 2008;13:552- 554.
Guía del cribado de cáncer de cuello uterino en España, 2014. Prog Obstet Ginecol 2014;57:1-53.
Roberts OA, Owonikoko KM, Abdus-Salam AA. Advanced carcinoma of the cervix in a 17 years-old-girl. J Obstet Gynaecol 2013;33:747-748.