2015, Number 2
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Med Int Mex 2015; 31 (2)
Acquired hemophilia. A rare cause of obstetric hemorrhage
Benardete-Harari DN, Sánchez-Cárdenas AG, Meraz-Ávila D, Nellen-Hummel H, Halabe-Cherem J
Language: Spanish
References: 49
Page: 174-180
PDF size: 422.95 Kb.
ABSTRACT
Acquired hemophilia is a rare autoimmune disease; about 7-14% of
all cases occur in the postpartum period in which an auto antibody
against factor VIII develops, presenting clinically with significant bleeding.
Should be suspected if there is a normal platelet count, normal
prothrombin time with prolongation of activated partial thromboplastin
not corrected with plasma. The management of postpartum hemophilia
aims to reduce bleeding to achieve a decrease of the mortality.
REFERENCES
Massimo F, Giovanni T, et al. Acquired factor VIII inhibitors in oncohematology: A systematic review. Crit Rev Oncol Hematol 2008;66:194-199.
Delgado J, Yimenez-Yuste V, Hernandez-Navarro F, Villar A. Acquired haemophilia: review and meta-analysis focused on therapy and prognostic factors. Br J Haematol 2003;121:21-35.
Boggio LN, Green D. Acquired hemophilia. Rev Clin Exp Hematol 2001;5:389-404.
Pruthi RK, Nichols WL. Autoimmune factor VIII inhibitors. Curr Opin Hematol 1999;6:314-322.
Mytopher K, Dudebout J, Card R, Gilliland B. Teaching Case Report: Acquired hemophilia A presenting post partum. CMAJ 2007;177:339-340.
Sedigheh Borna, Sedigheh Hantoushzadeh. Acquired hemophilia as a cause of primary postpartum hemorrhage. Arch Iranian Med 2007;10:107-110.
Mulliez S, Vantilborgh A, Devreese K. Acquired hemophilia: a case report and review of the literature. Int J Lab Hem 2014;36:398-407.
Yee TT, Pasi KJ, Lilley PA, Lee CA. Factor VIII inhibitors in haemophiliacs: a single-centre experience over 34 years, 1964-1997. Br J Haematol 1999;104:909-914.
Baudo F, de Cataldo F. Acquired factor VIII inhibitors in pregnancy: data from the Italian Haemophilia Register relevant to clinical practice. BJOG 2003;110:311-314.
Meiklejohn DJ, Watson HG. Acquired haemophilia in association with organ-specific autoimmune disease. Haemophilia 2001;7:523-525.
Sallah S, Nguien NP, Abdallah JM, Hanrahan LR. Acquired hemophilia in patients with hematologic malignancies. Arch Pathol Lab Med 2000;124:730-734.
Hauser I, Lechner K. Solid tumors and factor VIII antibodies. Thromb Haemost 1999;82:1005-1007.
Sallah S, Wan JY. Inhibitors against factor VIII in patients with cancer. Cancer 2001;91:1067-1074.
Franchini M. Postpartum acquired factor VIII inhibitors. Am J Hematol 2006;81:768-773.
Tengborn L, Baudo F, Huth-Kühne A, Knoebl P, et al. Pregnancy-associated acquired haemophilia A: results from the European Acquired Haemophilia (EACH2) registry. BJOG 2012;119:1529-1537.
Weston Smith SG, Revell P, Lawrie AS, Holland LJ, Savidge GF. The rapid development of an IgM inhibitor of porcine factor VIII in a patient with acquired haemophilia. Br J Haematol 1990;75:434-436.
Carmona E, Aznar JA, Jorquera JI, Villanueva MJ, Sanchez- Cuenca JM. Detection of two different anti-factor VIII/von Willebrand factor antibodies of the IgA class in a hemophilic patient with a polyclonal factor VIII inhibitor of the IgG class. Thromb Res 1991;63:73-84.
Reding MT. Immunological aspects of inhibitor development. Haemophilia 2006;12:30-36.
Reding MT, Lei S, Lei H, Green D, et al. Distribution of Th1- and Th2-induced anti-factor VIII IgG subclasses in congenital and acquired hemophilia patients. Thromb Haemost 2002;88:568-575.
Reding MT, Okita DK, Diethelm-Okita BM, Anderson TA, Conti-Fine BM. Human CD4+T-cell epitope repertoire on the C2 domain of coagulation factor VIII. J Thromb Haemost 2003;1:1777-1784.
Oldenburg J, Zeitler H, Pavlova A. Genetic markers in acquired haemophilia. Haemophilia 2010;16:41-45.
Pavlova A, Zeitler H, Scharrer I, Brackmann HH, Oldenburg J. HLA genotype in patients with acquired haemophilia A. Haemophilia 2010;16:107-112.
Karlsson H, Pérez C. Postpartum haemorrhage. An Sist Sanit Navar 2009;32:159-167.
Almagro D. La hemostasia en el embarazo. Rev Cub Hematol Inmunol Hemoter 2000;16:90-98.
Boudo F. Acquired factor VIII inhibitors in pregnancy: data from the Italian Hemophilia Register relevant to clinical practice. Int J Obstet Gynecol 2003;110:311-314.
Howland EJ, Palmer J, Lumley M, Keay SD. Acquired factor VIII inhibitors as a cause of primary postpartum hemorrhage. Eur J Obstet Gynecol 2002;103:97-98.
Astermark J, Donfield SM, Di Michele DM, et al. A randomized comparison of bypassing agents in hemophilia com plicated by an inhibitor: the FEIBA novoseven comparative (FENOC) study. Blood 2007;109:546-551.
Buseri F, Jeremiah Z, Kalio F. Influence and gestation period on some coagulation parameters among Nigerian antenatal women. Res J Med Science 2008;2:275-281.
Djelmis J, Ivanisevic M, Kurjak A, Mayer D. Hemostatic problems before, during and after delivery. J Perinat Med 2001;29:241-246.
Norris L. Blood coagulation. Best Pract Res Clin Obstet Gynaecol 2003;17:369-383.
Uchikova E, Ledjev I. Changes in haemostasis during normal pregnancy. Eur J Obstet Gynecol Reprod Biol 2005;119:185- 188.
Conte G, Figueroa G, Aravena P, Gonzáles N, Araos D, Cuneo M. Hemofilia adquirida tratada con anti-CD20, un anticuerpo antilinfocito B. Rev Méd Chil 2011;139:357-361.
Knoebl P, Marco P, Baudo F, Collins P, et al. Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). J Thromb Haemost 2012;10:622-631.
Solymoss S. Postpartum acquired factor VIII inhibitors: results of a survey. Am J Hematol 1998;59:1-4.
Ma AD, Carrizosa D. Acquired factor VIII inhibitors: pathophysiology and treatment. Hematol Am Soc Hematol Educ Program 2006;432-437.
Huth-Kuhne A, Baudo F, Collins P, Ingerslev J, et al. International recommendations on the diagnosis and treatment of patients with acquired hemophilia A. Haematologica 2009;94:566-575.
Collins P, Baudo F, Huth-Kuhne A, Ingerslev J, et al. Consensus recommendations for the diagnosis and treatment of acquired hemophilia A. BMC Res Notes 2010;3:161. 38.. Lossing TS, Kasper CK, Feinstein DI. Detection of factor VIII inhibitors with the partial thromboplastin time. Blood 1977;49:793-797.
Pruthi RK, Nichols WL. Autoimmune factor VIII inhibitors. Curr Opin Hematol 1999;6:314-322.
Ma AD, Carrizosa D. Acquired factor VIII inhibitors: pathophysiology and treatment. Hematology Am Soc Hematol Educ Program 2006;1:432-437.
Hauser I, Schneider B, Lechner K. Postpartum factor VIII inhibitors. A review of the literature with special reference to the value of steroid and immunosuppressive treatment. Thromb Haemost 1995;73:1-5.
Del Valle Rubido C y col. Hemofilia A adquirida posparto: guía de diagnóstico y tratamiento a raíz de un caso clínico. Prog Obstet Ginecol 2014.
Cabezas-Poblet M, Pérez-García R, Argíz-Muñiz A, Quintero- Méndez Y. Hemofilia adquirida en el postparto. Presentación de un caso. Rev Finlay 2012;2.
Michiels JJ. Acquired hemophilia A in womenpostpartum: clinical manifestations, diagnosis, and treatment. Clin Appl Thromb Hemost 2000;6:82-86.
García J, Vela J, García A, et al. Respuesta a largo plazo con rituximab en una paciente con hemofilia adquirida. Rev Invest Clin 2011;63:210-212.
García-Chavez J, Majluf-Cruz A, Montiel-Cervantes L, García- Ruiz Esparza M, Vela-Ojeda J. Rituximab therapy for chronic and refractory immune thrombocytopenic purpura: a long- term follow-up analysis. Ann Hematol 2007;86:871- 877.
Collins PW, Hirsch S, Baglin TP, Dolan G, et al. Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors’ Organisation. Blood 2007;109:1870-1877.
Tay L, Duncan E, Singhal D, Al-Qunfoidi R, et al. Twelve years of experience of acquired hemophilia A: trials and tribulations in South Australia. Semin Thromb Hemost 2009;35:769-777.
Solymoss S. Postpartum acquired factor VIII inhibitors: results of a survey. Am J Hematol 1998;59:1-4.
Hauser I, Schneider B, Lechner K. Post-partum factor VIII inhibitors. A review of the literature with special reference to the value of steroid and immunosuppressive treatment. Thromb Haemost 1995;73:1-5.