medigraphic.com
Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2015, Number 1

<< Back Next >>

Rev Esp Med Quir 2015; 20 (1)

Intestinal permeability and gut-liver axis

Gómez-Cortés E, Pérez-Cabeza de Vaca R, Martínez-Hernández JE, Guerrero-Celis N, Mondragón-Terán P, Alcaráz-Estrada SL, López-Hernández LB, Suárez-Cuenca JA

Language: Spanish
References: 31
Page: 83-89
PDF size: 585.56 Kb.


ABSTRACT

The liver-gut axis has been related with the progression of several diseases, including liver or general metabolic abnormalities. The gut provides a semi-permeable physiological barrier, mainly composed of proteins supporting cell-cell interactions as well as different transport systems regulated by internal and external factors. The molecules that reach portal blood trigger the response of the liver cell population; as a result, diverse protective and adaptive mechanisms or cell damage can be observed. This cell-cell communication is regulated by different physiological processes such as subclinical inflammation, oxidative stress, activation of proliferative pathways, apoptosis and/or fibrogenesis. Clinical benefits have been reported derived of the use of probiotic agents. Nevertheless, more robust translational research and clinical trials are required in order to establish specific recommendations with a higher therapeutic impact.


REFERENCES

  1. Fasano A, Shea-Donohue T. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol 2005;2(9):416-22.

  2. Menzies, I.S. Capítulo: Transmucosal passage of inert molecules in health and disease. In: Skadhauge, E. &Heintze, K., eds. Intestinal absorption and secretion. Falk Symposium 36. Lancaster: MTP Press Ltd, 1984: 527-43.

  3. Travis S, Menzies I. Intestinal permeability: functional assessment and significance. Clin Sci (Lond) 1992;82(5):471- 88.

  4. Madara, J.L. Loosening Tight Junctions. J. Clin Invest 1989;83:1089-94.

  5. Menzies I.S. Alimentary disachariduria in adults related to the osmolality of ingested solutions. Biochem J 1972;126:19-20.

  6. Fery, D.M, Butt, T.J., Broom, M.F., Hunter, J, Chadwick, V.S. Bacterial chemotactic oligopeptides and the intestinal mucosal barrier. Gastroenterology 1989;97:61-7.

  7. Siebler J, Galle PR, Weber MM. The Gut-Liver axis: Endotoxemia, inflammation, insulin resistance and NASH. J Hepatol 2008;48:1030-1034.

  8. Anderson, J. M., Van Itallie, C. M. Physiology and Function of the Tight Junction. Cold Spring Harb Perspect Biol 2009;1(2):a002584.

  9. Fuller E, Duckham C, Wood E. Disruption of epithelial tight junctions by yeast enhances the paracellular delivery of a model protein. Pharm Res 2007;24(1):37-47.

  10. Alan S. Fanning, Brian J. Jameson, Lynne A. The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoeskeleton. J Biol Chem 1998;273:29745-53.

  11. Schmidt E, Kelly SM, van der Walle CF. Tight junction modulation and biochemical characterisation of the zonula occludens toxin C-and N-termini. FEBS Lett 2007;581(16):2974- 80.

  12. González Alonso R. González García M, Albillos Martínez A. Physiopathology of bacterial translocation and spontaneous bacterial peritonitis in cirrhosis. Gastroenterología y Hepatología 2007;30(2):1-4.

  13. Markus F. Neurath, Ivan Fuss. Cytokine Gene Transcription By NF-kB Family Members in Patients With Inflammatory Bowel Disease. Annals of New York Academy of Sciences 1998;859:149-59.

  14. Ma TY, Iwamoto GK, Hoa NT, Akotia V, Pedram A, Boivin MA, et al. TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation. Am J Physiol Gastrointest Liver Physiol 2004;286(3):G367- 76.

  15. Ece A Mutlu, Phillip A Engen. Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. Particle and fibre toxicology 2011,8:19.

  16. Bruno P, Castaqliulo I, Di Leo V. Increased Intestinal Permeability on Obese Mice: New Evidence in the Pathogenesis of Nonalcoholic Steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2007;292(2):G518-25.

  17. Perrier C, Corthésy B. Gut permeability and food allergies. Clin Exp Allergy 2011;41(1):20-8.

  18. Li Q, Zhang Q, Wang M, Zhao S, Ma J, Luo N, et al. Interferon- gamma and tumor necrosis factor-alpha disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction. Clin Immunol 2008;126(1):67-80.

  19. Porras M, Martín MT, Torres R, Vergara P. Cyclical upregulated iNOS and long-term downregulated nNOS are the bases for relapse and quiescent phases in a rat model of IBD. Am J Physiol Gastrointest Liver Physiol 2006;290(3):G423-30.

  20. Hiroshi Kono, Ivan Rusyn. NADPH Oxidase-Derived Free Radicals are Key Oxidants in Alcohol-Induced Liver Disease. J Clin Invest 2000;106:867-72.

  21. Jiang F, Zhang Y, Gregory J. NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair. Pharmacol Rev 2006:63:218-42.

  22. Maeda S. NF-kB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis. Gastroenterology Research and Practice Vol 2010:1-10.

  23. Chang YZ. Migration of Hepatic Stellate Cells in Fibrotic Microenvironment of Diseased Liver Model. Hepatobiliary Pancreat Dis Int 2008;7(4):401-5.

  24. Hollander D. Crohn’s disease, TNF-alpha, and the leaky gut. The chicken or the egg? Am J Gastroenterol 2002;97(8):1867-8.

  25. Barboza Junior MS, Silva TM, Guerrant RL, Lima AA. Measurement of intestinal permeability using mannitol and lactulose in children with diarrheal diseases. Braz J Med Biol Res 1999;32(12):1499-504.

  26. Diepenhorst GM, van Ruler O, Besselink MG, van Santvoort HC, Wijnandts PR, Renooij W, Gouma DJ, Gooszen HG, Boermeester MA. Influence of prophylactic probiotics and selective decontamination on bacterial translocation in patients undergoing pancreatic surgery: a randomized controlled trial. Shock 2011;35(1):9-16.

  27. Ziegler TR, Cole CR. Small Bowel Bacterial Overgrowth in Adults: A Potential Contributor to Intestinal Failure. Current Gastroenterol Rep 2007;9(6):463-7.

  28. Sun XQ, Fu XB. Relationship between plasma D(-)-Lactacte and Intestinal Damage After Severe Injuries in Rats. World J Gastroenterol 2001;7(4):555-8.

  29. Halfon P, Bourliére M. Accuracy of Hyaluronic Acid Level for Predicting Liver Fibrosis Stages in Patients with Hepatitis C virus. Comp Hepatol 2005;4:6.

  30. Knittel T, Kobold D. Localization of Liver Myofibroblasts and Hepatic Stellate Cells in Normal and Diseased Rat Livers: Distinct Roles of (Myo-) Fibroblast Subpopulations in Hepatic Tissue Repair. Histochem Cell Biol 1999;112:387-401.

  31. Lo RS, Austin AS, Freeman JG. Is There a Role for Probiotics in Liver Disease? The Scientific World Journal 2014;2014:1- 7.a




2020     |     www.medigraphic.com