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2015, Número 1

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Rev Esp Med Quir 2015; 20 (1)


Permeabilidad intestinal y eje intestino–hígado

Gómez-Cortés E, Pérez-Cabeza de Vaca R, Martínez-Hernández JE, Guerrero-Celis N, Mondragón-Terán P, Alcaráz-Estrada SL, López-Hernández LB, Suárez-Cuenca JA

Idioma: Español
Referencias bibliográficas: 31
Paginas: 83-89
Archivo PDF: 585.56 Kb.


RESUMEN

El eje intestino-hígado se ha relacionado con la progresión de diferentes enfermedades, tanto hepáticas como del metabolismo general. El intestino es una barrera biológica semipermeable, selectiva, constituida de complejos de proteínas de unión intercelular y diferentes sistemas de transporte con capacidad de regulación por factores internos y externos. Las moléculas que ingresan a la circulación porta estimulan las poblaciones celulares del hígado, que originan o amplifican respuestas adaptativas de protección o daño. Esta comunicación está determinada por procesos como inflamación subclínica, estrés oxidativo, señales de proliferación, apoptosis o fibrogénesis. Intervenciones como el uso de probióticos han mostrado beneficios clínicos; sin embargo, se requieren más estudios traslacionales y ensayos clínicos para hacer recomendaciones específicas para un mayor impacto terapéutico.


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