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ISSN 0210-5187 (Electronic)

2003, Number 6

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Med Cutan Iber Lat Am 2003; 31 (6)

Dermatofibroma. A Ten Year Clinico-Pathological Analysis in the Department of Dermatopathology at the Hospital General de México

Moreno LLM, Mercadillo PP

Language: Spanish
References: 16
Page: 367-372
PDF size: 344.21 Kb.


ABSTRACT

Dermatofibroma is a common fibrohistiocytic tumor in the dermatology practice. It occurs mainly in young females, with prefered location on the limbs; it has a slow growth rate and it represents a mixture of fibroblastic and histiocytic cells with a special pattern. The Hospital General de México is one of the main institutions devoted to the diagnosis of cutaneous disease in Mexico, so we made an observational, retrospective, longitudinal, open and descriptive study; we included 187 dermatofibromas in order of specify their clinico-pathological features, the period revised was from January 1991 to December 2000. It was found a 1.23% frequency in relation with all the cutaneous samples evaluated at those times. The mainly affected age group was 21-30 year old, with a predominance female:male in 4:1.The main topography included the limbs, and the arms and forearms in second place. Using the histopathological analisis the frecuency of classic dermatofibromas was 62.24%, atypical dermatofibromas were 18.71%, fibrous histiocytomas 14.43% and histiocytomas represented 1.6%. Simple acanthosis followed by epidermal atrophy were the main findings in the epidermis. The features of the dermis were characterized by a predominant storiform pattern, epithelioid cells, collagenous rings, stromal edema, hemosiderophages, neovascularization, xanthomatized cells and even a minimal number of mitosis. We found one case of atypical dermatofibroma with bone metaplasia and 2 cases of sclerotic collagenoma-like appearance in the core of tumors. We classified 3 lichenoid and 2 erosive dermatofibroma cases. It can be concluded that there is a lack of adecuate and specific diagnostic route on order to clasify the dermatofibromas and related fibrohistiocytic neoplasms, and also, the histologic variants do not change the clinical evolution and outcome.


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