medigraphic.com
ISSN 0210-5187 (Electronic)

2003, Number 4

<< Back Next >>

Med Cutan Iber Lat Am 2003; 31 (4)

Antithyroid Drugs Induced Systemic Lupus Erythematous

Avilés IJA, Huerta BM, Suárez FR, Lázaro OP

Language: Spanish
References: 12
Page: 243-245
PDF size: 158.42 Kb.


ABSTRACT

A 37 years-old woman diagnosed of Graves disease, show up a drug eruption due to thiamazole and after that a serious propylthiouracil induced systemic lupus erythematous (SLE). Inmmunologic and histologic findings allowed to confirm the diagnose of antithyroid drugs induced SLE. The patient was treated with systemic corticoids and azathioprine, but disease was not controlled till antithyroid drugs were removed and a thyroidectomy was performed.


REFERENCES

  1. Pramatarov KD: Drug-induced lupus erythematosus. Clin Dermatol 1998; 16: 367-77.

  2. Beer KR, Lorincz AL, Medenica MM, Albertini J, Baron J, Drinkard L, Swartz T. Insecticide-induced lupus erythematosus. Int J Dermatol. 1994; 33:860-862.

  3. Burry JN, Lipstick and lupus erythematosus. N Engl J Med. 1969; 281:620-621.

  4. Wring ES, Aspet SP. Observations on the use of propylthiouracil in hyperthyroidism with especial reference to long term treatment. John’s Hopkins Med 1952;90:201–27.

  5. Prasad GV, Bastacky S, Johnson JP. Propylthiouracil-induced diffuse proliferative lupus nephritis: review of immunological complications. J Am Soc Nephrol 1997;8:1205-10.

  6. Sato-Matsumura KC, Koizumi H, Mazumura T et al.Lupus erythematosus-like syndrome induced by thiamazole and propylthiouracil. J Dermatol (Tokyo) 1994;21: 501–7.

  7. Rubin RL: Etiology and mechanisms of drug-induced lupus. Curr Opin Rheumatol 1999; 11: 357-63.

  8. Searles RP, Plymate SR, Troup GM. Familial thioamide-induced lupus syndrome in thyrotoxicosis.J Rheumatol. 1981;8:498-500.

  9. Kawachi Y, Nukaga H, Hoshino N, et al. ANCA-associated vasculitis and lupus-like syndrome caused by methymazole. Clin Exp Dermatol 1995;20:345–7.

  10. Herlin T, Birkebaek NH, Wolthers OD, Heegaard NH, Wiik A. Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism.Scand J Rheumatol. 2002;31:46-9.

  11. Yamada A, Sato K, Hara M, Tochimoto A, Takagi S, Hizuka N, Takano K. Propylthiouracil-induced lupus-like syndrome developing in a Graves’ patient with a sibling with systemic lupus erythematosus. Intern Med. 2002;41:1204-8.

  12. Thong HY, Chu CY, Chiu HC. Methimazole-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and lupus-like syndrome with a cutaneous feature of vesiculo-bullous systemic lupus erythematosus. Acta Derm Venereol. 2002;82:206-8.




2020     |     www.medigraphic.com