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2003, Number 1

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Med Cutan Iber Lat Am 2003; 31 (1)

Current Concepts in Immunophatology of the Skin

Robledo PMA, Díaz LA

Language: Spanish
References: 126
Page: 3-16
PDF size: 262.58 Kb.


ABSTRACT

This review covers the most relevant scientific information on the immunopathology of the autoimmune blistering diseases, lichen planus and lupus. Emphasis has been placed on the description of the immunoassays that are important and practical for the diagnosis of these diseases. The immunofluorescence techniques continue to be important diagnostic tests available to most clinicians. They provide diagnostic, and in some cases prognostic information, useful in the management of these diseases, e.g. pemphigus. The molecular characterization of the cutaneous antigens that constitute autoantibodies targets and that are present in these autoimmune diseases have allowed investigators to develop newer assays, such as ELISA, immunoprecipitation and immunoblotting, all applicable to the precise diagnosis of each disease. The use of recombinant skin antigens to test the responses of the patients T and B lymphocytes will provide important new information on the pathogenesis of these diseases.


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