medigraphic.com
ISSN 0016-3813 (Print)

2004, Number 4

Next >>

Gac Med Mex 2004; 140 (4)

Neurodevelopmental Disorders in Children with an Antecedent of Subependymal/Intraventricular Hemorrhage at 3 Years of Age.

Fernández-Carrocera LA, González-Mora E

Language: Spanish
References: 54
Page: 367-373
PDF size: 58.33 Kb.


ABSTRACT

Intraventricular and subependymal hemorrhage are common complications among preterm infants. The aim of the present study was to assess its implication in the neurodevelopment at 3 years of age. Material and methods: cerebral ultrasonography with evidence of any stage of intraventricular hemorrhage (Papille’s classification) during neonatal period and a neurologic evaluation at 3 years of age were performed on each patient. One hundred twenty four patients were enrolled and assigned to four groups according the intraventricular hemorrhage (IVH) stage: Grade I, 14 patients, grade II, 84, grade III, 22, and grade IV nine patients. Results: morbility was similar for all groups; hydrocephalus was more frequent in group III (73%), and in group IV chronic pulmonary disease (77%) was more frequent. Forty five percent of the sample showed neurologic alterations with the greatest proportion in group IV (89%); OR for groups III and IV was 3.51 with a 95% confidence interval of (1.49, 8.28 p= 0.005). Grades III&IV showed lowest Terman Merril scores and grade IV scores were within the range of mental retardation. No statistical difference was found between grades at audition evaluation. Conclusions: neurologic alterations were greater in poorer grades of IVH, and risk will increment for grades III and IV. Associated pathologies for IVH grades III and IV were hydrocephalus and chronic pulmonary disease.


REFERENCES

  1. Volpe JJ. Intraventricular hemorrhage in the premature infant-current concepts. Part I. Ann Neurol 1989;25:3-11.

  2. Volpe JJ. Intraventricular hemorrhage in the premature infant-current concepts. Part II. Ann Neurol 1989;25:109-116.

  3. Ahmann PA. Intraventricular hemorrhage in high risk premature infants: incidence and outcome. Ann Neurol 1980;8:118-124.

  4. Philip AGS. Intraventricular hemorrhage in preterm infants: declining incidence in the 1980’s. Pediatrics 1989;84:797-801.

  5. Hanigan WC, Morgan AM, Anderson RJ, Bradle P, Cohen HS, Cusak TJ, Thomas-McCauley T, Miller TC. Incidence and neurodevelopmental outcome of periventricular hemorrhage and hydrocephalus in a regional population of very low birth weight infants. Neurosurgery 1991;29:701-706.

  6. Hawgood S, Spong J, Yu VYH. Intraventricular hemorrhage. Incidence and outcome in a population of very-low-birth weight infant. Am J Dis Child 1984;138:136-39.

  7. Van De Bor M, Van Bel F, Lineman R, Ruys JH. Perinatal factors and periventricular-intraventricular hemorrhage in preterm Infants. AJDC 1986;140: 1125-1130.

  8. Avery B. Neonatology. Philadelphia, PA, USA: JB Lippincott Co.;1994. pp. 1127-1134.

  9. Brann BS, Qualls C, Papille L, Wells L, Werner S. Measurement of progressive cerebral ventriculomegaly in infants after grades III and IV intraventricular hemorrhages. J Pediatr 1990;117:615-621.

  10. Anderson AE, Wildin SR, Woodside M, Swank,PR, Smith K.E, Denson SE, Miller CL, Butler IJ, Landry SH. Severity of Medical and neurologic Complications as a determinant of neurodevelopmental outcome at 6 and 12 months in very low birth weight infants. J Child Neurol 1996;11:215-219.

  11. Dubowitz LMS, Dubowitz V, Palmer PG, Miller G, Fawer CL, Levene MI. Correlation of neurologic assessment in the preterm newborn infant with outcome at 1 year. J Pediatr 1984;105:452-456.

  12. Futagi Y, Tagawa T, Otani K. Primitive reflex profiles in infants: differences basad on categories of neurological abnormality. Brain Dev 1992;14:294-298. 13. Catto-Smith AG, Yu VYH, Bajuk B, Orgill AA, Astbury J. Effect of neonatal periventricular haemorrhage on neurodevelopmental outcome. Arch Dis Child 1985;60:8-11.

  13. Fazzi E, Lanzi G, Gerardo A, Ometto A, Orcesi S, Rondini G. Neurodevelopmental outcome in very-low-birth-weight infants with or without periventricular haemorrhage and/or leukomalacia. Acta Paediatr 1992;81:808-811.

  14. Roth SC, Baudin J, McCormick DC, Edwards AD, Towsend J, Stewart AL, Reynolds EOR. Relation between ultrasound appearance of the brain of very preterm infants and neurodevelopmental impairment at eight years. Dev Med Child Neurol 1993;35:755-768.

  15. Fazzi E, Orcesi S, Telesca C, Ometto A, Rondini G, Lanzi G. Neurodevelopmental outcome in very low birth weight infant at 24 months and 5 to 7 years of age: changing diagnosis. Pediatr Neurol 1997;17:240-248.

  16. Allan WC, Vohr B, Makuch RW, Katz KH, Ment LR. Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage. Arch Pediatr Adolesc Med 1997;151:580-585.

  17. Morgan AM, Aldag JC. Early Identification of cerebral palsy using a profile of abnormal motor patterns. Pediatrics 1996;98:692-697.

  18. Roth SC, Baudin J, Pezzani GM, Townsend J, Reynolds EOR, Stewart AL. Relation between neurodevelopmental status of very preterm infants at one and eight years. Dev Med Child Neurol 1994;36:1049-1062.

  19. Scher MS, Dobson V, Carpenter NA, Guthrie RD. Visual and Neurological outcome of infant with periventricular leukomalacia. Dev Med Child Neurol 1989;31:353-365

  20. Chaplin ER, Goldstein GW, Myerberg DZ, Hunt JV, Tooley WH. Posthemorrhagic hydrocephalus in the preterm Infant. Pediatrics 1980;65:901-909.

  21. Guzzetta F, Mercuri E, Spano M. Mechanisms and evolution of the brain damage in neonatal post-hemorrhagic hydrocephalus. Child Nerv Syst 1995;11:293-296.

  22. Costello DW, Borawski E, Friedman H, Redline R, Fanaroff AA, Hack M. Perinatal correlates of cerebral palsy and other neurologic impairment among very low birth weight children. Pediatrics 1998;102:315-322.

  23. Papile LA. Incidence and evolution of subependymal and intraventricular hemorrhage. A study of infants with birth weights less than 1500 gm. J Pediatr 1978;92:529-534.

  24. Examen clínico neurológico, por Miembros de la Clinica de Mayo, La Prensa Medica Mexicana, S.A. de C.V. 3ª ed. reimpresión 1988.

  25. Lowe. Audiometría en el niño. Implicaciones pedagógicas. 1ª ed. México: Editorial Médica Panamericana;1981.

  26. Launay CL. Trastornos del lenguaje, la palabra y la voz en el niño.2ª ed. Barcelona. España: Toray Masson;1984.

  27. Fernández CL, Cortázar ET, Garza MS, Rodríguez BL, Udaeta ME. Alteraciones del neurodesarrollo en el primer año de vida en neonatos que pesaron 2000 gramos o menos al nacer.Neurologia 1992;7:98-101.

  28. Clark RH, Dykes FD, Bachman TE, Ashurst JT. Intraventricular hemorrhage and high-frequency ventilation: a meta-analysis of prospective clinical trials. Pediatrics 1996;98:1058-1061.

  29. Fernández CL, Barzola BA, Ortigosa CE, Ibarra RP, Martínez CC, Rodríguez PL, Barrera RR. Neurodesarrollo al año de edad en neonatos con peso igual o menor a 1000 g al nacer. Bol Med Hosp Infant Mex 1995;52:572-80.

  30. Guzzetta F, Shackelford GD, Volpe S, Perlman JM, Volpe JJ. Periventricular intraparenchymal echodensities in the premature newborn: critical determinant of neurologic outcome. Pediatrics 1986;78:995-1006

  31. Pidcock FS, Grazlani LJ, Stanley C, Mitchell DG, Merton D. Neurosonographic features of periventricular echodensities associated with cerebral palsy in preterm infants. J Pediatr 1990;116:417-422.

  32. Wiswell TE, Graziani LJ, Kornhauser MS, Stanley C, Merton DA, McKee L, Spitzer AR. Efects of hypocarbia on the development of cystic periventricular leukomalacia in premature infants treated with high-frequency jet ventilation. Pediatrics 1996;98:918-24.

  33. Ford LM, Steichen J, Steichen A, Babcock D, Fogelson MH. Neurologic status and Intracranial hemorrhage in very-low-birth-weight preterm infant. AJDC. 1989;143:1186-1190.

  34. Van de Bor M, Ens-Dokkum M, Schreuder AM, Veen S, Brand R, Verloove-Vanhorick SP. Outcome of periventricular-intraventricular haemorrhage at five years of age. Dev Med Child Neurol 1993;35:33-41.

  35. Prechtl HFR, Einspieler C, Cioni G, Bos FA, Ferrari F, Sontheimer D. An early marker for neurological deficit after perinatal brain. Lancet 1997;349:1361-1363.

  36. Bozynski MEA, Nelson MN, Malaton TAS, O’Donnell, Naughton PM, Vasan U, Meier WA, Ploughman L. Prolonged mechanical ventilation and intracranial hemorrhage: impact on developmental progress through 18 months in infants weighing 1200 grams or less at birth. Pediatrics 1987;5:670-76.

  37. Andersen G. Prediction of outcome in 164 infant born after 24 to 28 weeks gestation. Acta Paediatr Scand 1989;(Suppl)360:56-61.

  38. Ikonen RS, Janas MO, Koivikko MJ, Laippala P, Kuusinen EJ. Hyperbilirubinemia, hypocarbia and periventricular leukomalacia in preterm infant: relationship to cerebral palsy. Acta Paediatr 1992;81:802-807.

  39. Perlman JM, Risser R, Broyles RS. Bilateral cystic periventricular leukomalacia in the premature infant: associated risk factors. Pediatrics 1996;97:822-827.

  40. Pikus HJ, Levy ML, Gans W, Mendel E, McComb JG. Outcome, cost analysis, and long-term follow-up in preterm infants with masive grade IV germinal matrix hemorrhage and progressive hydrocephalus. Neurosurgery 1997;40:983-989.

  41. Bozynski MEA, Nelson MN, Genaze D, Rosati-Skertich C, Matalon TAS, Vasan U, Naughton PM. Cranial ultrasonography and the prediction of cerebral palsy in infants weighing <1200 grams at birth. Dev Med Child Neurol 1988;30:342-348.

  42. Resch B, Gedermann A, Maurer U, Ritschl E, Muller W. Neurodevelopmental outcome of hydrocephalus following intra-periventricular hemorrhage in preterm infants: short- and long-term results. Child Nerv Syst 1996;12:27-33. 44. Resnick MB, Stralka K, Carter RL, Ariet M, Bucciarelli RL, Furlough RR et al. Effects of birth weight and sociodemographic variables on mental development of neonatal intensive care unit survivors. Am J Obstet Gynecol 1990;162:374-378.

  43. Resnick MB, Gomatam SV, Carter RL, Ariet M, Roth J, Kilgore KL, et al. Educational disabilities of neonatal intensive care graduates. Pediatrics 1998;102:308-314.

  44. The Scottish Low Birthweight Study Group. The Scottish Low Birthweight Study: II. Language attainment, cognitive status, and behavioural problems Arch Dis Child 1992;67:682-686.

  45. Barrera RR, Fernández CL, Ortigosa CE, Martínez CC, Rodríguez PL, Ibarra RP. Neurodesarrollo al año de vida en pacientes con dislasia broncopulmonar. Bol Med Hosp Infant Mex 1995;52:572-580.

  46. Singer L, Yamashita T, Lilien L, Collin M, Baley J. A longitudinal study of developmental outcome of infants with bronchopulmonary dysplasia and very low birth weight. Pediatrics 1997;100:987-993.

  47. Levene M, Dowling S, Graham M, Fogelman K., Galton M, Phillips M. Impaired motor function (clumsiness) in 5 year old children: correlation with neonatal ultrasound scans. Arch Dis Child 1992;67:687-690.

  48. Dall’Oglio AM, Bates E, Volterra V, Di Capua M, Pezzini G. Early cognition, communication and language in children with focal brain Injury. Dev Med Child Neurol 1994;36:1076-1098.

  49. The Scottish Low Birthweight Study Group. The Scottish Low Birthweight Study: I. Survival, growth, neuromotor and sensory impairment. Arch Dis Child 1992;67:675-681.

  50. Waugh J, O’Callaghan MJ, Tudehope DI, Mohay HA, Burns YR, Gray PH, Rogers YM. Prevalence and aetiology of neurological impairment in extremely low birthweight infants.J Paediatr Child Health, 1996;32:120-124.

  51. Drillien CM, Pickering RM, Drummond MB. Predictive value of screening for different areas of development. Dev Med Child Neurol 1988;30:294-305.

  52. Aylward GP, Pfeiffer SI, Wright A, Verhulst SJ. Outcome studies of low birth weight infants published in the last decade: a metaanalysis. J Pediatr 1989;115:515-520.

  53. Inder TE, Wells SJ, Mogridge NB, Spencer C, Volpe JJ. Defining the nature of the cerebral abnormalities in the premature infant: a qualitative magnetic resonance imaging study. J Pediatr 2003;143:171-179.

  54. Okumura A, Hayakawa F, Kato T,Maruyama K,Kubota T, Sizuki M, Kidokoro H, Kuno K, Watanabe K. Abnormal sharp transients on electroencephalograms in preterm infants with periventricular leukomalacia. J Pediatr 2003;143:26-30.




2020     |     www.medigraphic.com