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2004, Number 3

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Gac Med Mex 2004; 140 (3)

Phosphorylation of Tau and Alzheimer’s Disease.

García T, Jay D

Language: Spanish
References: 52
Page: 329-334
PDF size: 528.67 Kb.


ABSTRACT

Tau is an important component of neuronal cytosqueleton; the protein stabilizas microtubules, maintains cell shape and axonal transport mechanisms. Howevwe, for unknown reasons tau experiments important postranslation modifications including enhanced phosphorylation due to unbalanced activity between kinases and phosphatases, affecting its normal biological function. Under these circumstances tau begins to aggregate into neurofibrillary tangles (NFTS) complexes which are pathological hallmarks of Alzheimer's disease together with senile plaques. This review is mainly concerned with the role that different kinase play into the regulation of tau structure and function.


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